SGOL1
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Official Full Name
shugoshin-like 1 (S. pombe) -
Overview
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. -
Synonyms
SGOL1;shugoshin-like 1 (S. pombe);SGO;Sgo1;NY-BR-85;shugoshin-like 1;hSgo1;shugoshin 1AB protein;shugoshin 1CD protein;shugoshin 1EF protein;shugoshin 1GH protein;shugoshin 1KL protein;serologically defined breast cancer antigen NY-BR-85
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SGOL1-15040M | Recombinant Mouse SGOL1 Protein | Mammalian Cell | Mouse | His |
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| SGOL1-4441C | Recombinant Chicken SGOL1 | Mammalian Cell | Chicken | His |
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| SGOL1-1594HCL | Recombinant Human SGOL1 cell lysate | Human | Non |
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| SGOL1-8105M | Recombinant Mouse SGOL1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SGOL1-8105M-B | Recombinant Mouse SGOL1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SGOL1 involved in several pathways and played different roles in them. We selected most pathways SGOL1 participated on our site, such as Aurora B signaling,Cell Cycle,Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with SGOL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitotic Anaphase | B9D2,ERCC6L,NDC80,CDCA5,PDS5B,RANGAP1B,CENPN,NSL1,CENPI,AHCTF1 |
| Oocyte meiosis | CCNE1,CDC25C,PPP2CA,PPP3CCB,FBXW11,CALM3,PPP2R5B,PRKACAB,PPP3CA,PPP1CC |
| Mitotic Prometaphase | MLF1IP,AHCTF1,NCAPG,SPC25,NDC80,DSN1,NSL1,CENPP,CENPC1,PDS5B |
| Mitotic Metaphase and Anaphase | CENPI,PDS5A,NDEL1B,AHCTF1,SKA1,TMPO,SKA2,CENPO,CLIP1,RCC2 |
| Aurora B signaling | NCAPH,AURKB,TACC1,NPM1,PEBP1,KIF20A,INCENP,NCAPD2,RACGAP1,NSUN2 |
| Cell cycle | PSMC3IP,CCNA1,TEX12,LMNB1,YWHABB,BUB1,TUBGCP3,RBL2,THRSP,CCND2A |
| M Phase | APITD1,SETB,KNTC1,NDEL1A,VRK1,KIF2B,DULLARD,VRK2,NEK6,CNEP1R1 |
| Cell Cycle, Mitotic | ANKLE2,KIF18A,MCPH1,CEP57,AURKB,CP110,SPC24,CTDNEP1B,LIN9,DCTN1 |
Protein Function
SGOL1 has several biochemical functions, for example, kinase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SGOL1 itself. We selected most functions SGOL1 had, and list some proteins which have the same functions with SGOL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinase binding | STUB1,RB1,PRKCD,LDHA,JAKMIP1,DLG1,WWC3,CHP,TRIP6,HSP90AB1 |
| protein binding | NAB2,NFE2L1,GMIP,PTPN23,TFAM,LAIR1,SNAI2,MAP4K4,CCDC28B,AMIGO2 |
Interacting Protein
SGOL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SGOL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SGOL1.
PPP2R5D;PPP2R5A;PPM1A;PPP2CA;Ppp2r1a;TCEB1;ZNF768;NCOR1;DYSF;ALDH1B1;CBX5;LIMS1;CTSC;SET;RAD51;ECH1;SUPT6H
Resources
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References
- Chetaille, P; Preuss, C; et al. Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm. NATURE GENETICS 46:1245-1249(2014).
- Krantz, ID; et al. Cohesin embraces new phenotypes. NATURE GENETICS 46:1157-1158(2014).
