SGIP1
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Official Full Name
SH3-domain GRB2-like (endophilin) interacting protein 1 -
Overview
SGIP1 functions as an endocytic protein that affects signaling by receptors in neuronal systems involved in energy;homeostasis via its interaction with endophilins (see SH3GL3; MIM 603362) (Trevaskis et al., 2005 (PubMed 15919751);and Uezu et al., 2007 (PubMed 17626015)). -
Synonyms
SGIP1;SH3-domain GRB2-like (endophilin) interacting protein 1;SH3-containing GRB2-like protein 3-interacting protein 1;DKFZp761D221;endophilin-3-interacting protein;FLJ33378;FLJ43054;DKFZp686A16142
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SGIP1-2630H | Recombinant Human SGIP1, GST-tagged | E.coli | Human | GST | 559-859aa | |
| SGIP1-4181R | Recombinant Rhesus monkey SGIP1 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| SGIP1-3997R | Recombinant Rhesus Macaque SGIP1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SGIP1-3997R-B | Recombinant Rhesus Macaque SGIP1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
SGIP1 involved in several pathways and played different roles in them. We selected most pathways SGIP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SGIP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SGIP1 has several biochemical functions, for example, SH3 domain binding,microtubule binding,phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SGIP1 itself. We selected most functions SGIP1 had, and list some proteins which have the same functions with SGIP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | DOCK4,SHANK1,VASP,FAM125A,EPS15,CYBA,MAPK15,DOCK1,QKI,PLSCR4 |
| protein binding | NME3,TLR2,NTRK3,CAPRIN2,TPP2,EIF1AY,OFCC1,SH3GL2,CCT5,IFI35 |
| microtubule binding | KLC3,CLIP1,JAKMIP1,PLK1,KIAA1128,JAKMIP2,GABARAPL2,KIF20B,MTAP1A,CAMSAP2A |
| phospholipid binding | PON1,RASAL1,APOEA,ABCA1,APOH,APOA1,SPTB,BAD,SDPR,LC3 |
Interacting Protein
SGIP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SGIP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SGIP1.
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References
- Cummings, N; Shields, KA; et al. Genetic variation in SH3-domain GRB2-like (endophilin)-interacting protein 1 has a major impact on fat mass. INTERNATIONAL JOURNAL OF OBESITY 36:201-206(2012).
- Craft, GE; Graham, ME; et al. The in vivo phosphorylation sites in multiple isoforms of amphiphysin I from rat brain nerve terminals. MOLECULAR & CELLULAR PROTEOMICS 7:1146-1161(2008).
- Trevaskis, J; Walder, K; et al. SH3-domain GRB2-like (endophilin) interacting protein 1 (SGIP1), a novel neuronal protein that regulates energy balance. OBESITY RESEARCH 12:A23-A23(2004).
