SERPING1
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Official Full Name
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 -
Overview
This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. -
Synonyms
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1;SERPING1;C1IN;C1NH;HAE1;HAE2;C1INH;C1 INH;C1 inhibitor;esterase inhibitor;Serine (or cysteine) proteinase inhibitor clade G member 1;OTTHUMP00000197004;Serpin G1;C1-inhibiting factor;C1-INH
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- HEK293
- CHO
- Normal human serum (shown by certified tests to be negative for HBsAg, HTLV-I/II, STS, and for antibodies to HCV, HIV-1 and HIV-II)
- Mammalian Cell
- E.coli
- Human Cell
- HEK293T
- Mammalian cells
- Human Plasma
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
SERPING1 involved in several pathways and played different roles in them. We selected most pathways SERPING1 participated on our site, such as Complement and coagulation cascades,Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPING1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pertussis | C1S,CD14,IL12B,RELA,C1QA,C4BP,PYCARD,MAPK3,IL23,C1QC |
| Complement and coagulation cascades | F13B,MASP1,THBD,PLAT,F7,F10,CFB,CFD,SERPINA1E,CFI |
Protein Function
SERPING1 has several biochemical functions, for example, protein binding,serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPING1 itself. We selected most functions SERPING1 had, and list some proteins which have the same functions with SERPING1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase inhibitor activity | WFDC5,PCSK1N,WFDC2,APPB,SERPINC1,WFDC13,WFDC6B,SERPINE1,AMBP,SPINK4 |
| protein binding | CEP76,ATP6V1B2,HDDC3,KIF5C,ABCD2,SEPT3,MAP2K5,COPS3,SBDS,RBM12B |
Interacting Protein
SERPING1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPING1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPING1.
p27958-pro_0000037573;f_hcvh;NR4A1;BAG6;purL;smc3;ALB
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