SERPINB8
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Official Full Name
serpin peptidase inhibitor, clade B (ovalbumin), member 8 -
Overview
The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular;and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor;suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that;consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 (PubMed 2690952)). A critical portion of;the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member;of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high;degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a;serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 (PubMed;9268635)). -
Synonyms
SERPINB8;serpin peptidase inhibitor, clade B (ovalbumin), member 8;PI8, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8;serpin B8;CAP2;cytoplasmic antiproteinase 2;CAP 2;CAP-2;OTTHUMP00000067000;OTTHUMP00000067001;Peptidase inhibitor 8;PI-8;PI8;Protease inhibitor 8 (ovalbumin type);Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 8;Serpin peptidase inhibitor clade B (ovalbumin) member 8;SPB8_HUMAN;serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Insect Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- Non
- His
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SERPINB8-2597H | Recombinant Human SERPINB8, GST-tagged | E.coli | Human | GST | N-term-242aa | |
| SERPINB8-31160TH | Recombinant Human SERPINB8 | Wheat Germ | Human | Non | 242 amino acids |
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| SERPINB8-686H | Recombinant Human serpin peptidase inhibitor, clade B (ovalbumin), member 8, His-tagged | E.coli | Human | His | 1-374 a.a. |
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| SERPINB8-665MCL | Recombinant Mouse SERPINB8 cell lysate | Insect Cell | Mouse | Non |
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| SERPINB8-1005H | Recombinant Human SERPINB8 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| SERPINB8-2250H | Recombinant Human SERPINB8 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| SERPINB8-465HF | Recombinant Full Length Human SERPINB8 Protein | In Vitro Cell Free System | Human | Full L. 242 amino acids |
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Involved Pathway
SERPINB8 involved in several pathways and played different roles in them. We selected most pathways SERPINB8 participated on our site, such as Dissolution of Fibrin Clot,Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINB8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Dissolution of Fibrin Clot | SERPINE2,HRG,S100A10A,ANXA2A,S100A10,S100A10B,ANXA2,ANXA2B,SERPINF2B |
| Hemostasis | GNA13,KIFAP3,KIF3B,KIF11,ANXA2B,ANGPT2A,WDR1,ZFPM2A,OSTN,D-AKAP2 |
Protein Function
SERPINB8 has several biochemical functions, for example, protein binding,serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINB8 itself. We selected most functions SERPINB8 had, and list some proteins which have the same functions with SERPINB8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase inhibitor activity | WFDC6,SERPINF1,SERPINB5,KAL1,A2ML1,PAPLN,Serpina1b,SERPINH1,SERPINA1,SPINT1B |
| protein binding | RAD51B,KANK2,ITGB2,CYTH2,PKN1,2610109H07Rik,PAK3,ATG101,HSD17B8,HSPG2 |
Interacting Protein
SERPINB8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINB8 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINB8.
Resources
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References
- Lim, W; Kim, JH; et al. Avian SERPINB11 Gene: Characteristics, Tissue-Specific Expression, and Regulation of Expression by Estrogen. BIOLOGY OF REPRODUCTION 85:1260-1268(2011).
