Serpinb10
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Official Full Name
serpin peptidase inhibitor, clade B (ovalbumin), member 10 -
Overview
The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular;and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor;suppression, apoptosis, and cell migration. Serpins are characterized by a well-conserved tertiary structure that;consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 (PubMed 2690952)). A critical portion of;the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-10 (PI10; SERPINB10) is a;member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a;high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a;serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 (PubMed;9268635)). -
Synonyms
SERPINB10;serpin peptidase inhibitor, clade B (ovalbumin), member 10;PI10, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 10;serpin B10;bomapin;protease inhibitor 10 (ovalbumin type;bomapin);PI10;Protease inhibitor 10;Protease inhibitor 10 (ovalbumin type bomapin);Serpin peptidase inhibitor clade B (ovalbumin) member 10;peptidase inhibitor 10;protease inhibitor 10 (ovalbumin type, bomapin);serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 10;PI-10
Recombinant Proteins
- Mouse
- Rhesus macaque
- Rat
- Chicken
- Human
- Insect Cells
- Mammalian Cell
- Insect Cell
- HEK293T
- Yeast
- HEK293
- His
- Non
- Myc&DDK
- N-His-sumostar
- His&Fc&Avi
Involved Pathway
Serpinb10 involved in several pathways and played different roles in them. We selected most pathways Serpinb10 participated on our site, such as Amoebiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Serpinb10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amoebiasis | PIK3R3,GNA14,IL1B,COL5A2,PIK3CG,LAMB2,PLCB4,CSF2,NFKB1,C8G |
Protein Function
Serpinb10 has several biochemical functions, for example, peptidase inhibitor activity,serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Serpinb10 itself. We selected most functions Serpinb10 had, and list some proteins which have the same functions with Serpinb10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase inhibitor activity | SERPINH1A,SERPINB1C,SERPINA3M,WFDC13,WFDC1,SPINK3,SERPINA10A,SERPINA1D,SERPINA1L,SERPINA1 |
| peptidase inhibitor activity | PI15,SPINK13,NGP,SERPINA3M,SPINK3,PI16,WFDC15A,PTTG1,MUG2,SERPINA3K |
Interacting Protein
Serpinb10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Serpinb10 here. Most of them are supplied by our site. Hope this information will be useful for your research of Serpinb10.
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References
- Lindskog, C; Korsgren, O; et al. Novel pancreatic beta cell-specific proteins: Antibody-based proteomics for identification of new biomarker candidates. JOURNAL OF PROTEOMICS 75:2611-2620(2012).
