SEPT9
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Official Full Name
septin 9 -
Overview
This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
SEPT9;septin 9;MLL septin like fusion , MSF;septin-9;AF17q25;KIAA0991;MSF1;Ov/Br septin;PNUTL4;SeptD1;AF17q25;Cell division control protein septin D1;KIAA0991;MLL septin like fusion protein;MLL septin-like fusion protein;MLL septin-like fusion protein MSF-A;MSF;MSF1;Ov/Br septin;Ovarian/breast septin alpha;Ovarian/Breast septin;PNUTL4;SEPT9;SEPT9_HUMAN;Septin 9;Septin D1;Septin-9;SINT1;septin D1;ovarian/breast septin;MLL septin-like fusion protein MSF-A;MSF;NAPB;SINT1
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SEPT9-2601H | Recombinant Human SEPT9 protein, His-tagged | E.coli | Human | His | 250-568 aa | |
| SEPT9-14899M | Recombinant Mouse SEPT9 Protein | Mammalian Cells | Mouse | His |
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| SEPT9-2404C | Recombinant Chicken SEPT9 | Mammalian Cells | Chicken | His |
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| SEPT9-5328R | Recombinant Rat SEPT9 Protein | Mammalian Cells | Rat | His |
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| SEPT9-1952HCL | Recombinant Human SEPT9 293 Cell Lysate | HEK293 | Human | Non |
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| SEPT9-2421M | Recombinant Mouse SEPT9 Protein (1-583 aa), His-tagged | E.coli | Mouse | His | 1-583 aa |
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| SEPT9-4987R | Recombinant Rat SEPT9 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SEPT9-4987R-B | Recombinant Rat SEPT9 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SEPT9-8030M | Recombinant Mouse SEPT9 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SEPT9-8030M-B | Recombinant Mouse SEPT9 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SEPT9 involved in several pathways and played different roles in them. We selected most pathways SEPT9 participated on our site, such as Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEPT9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bacterial invasion of epithelial cells | MAD2L2,ARPC5L,WASF2,CRK,CBL,ARPC3,ELMO1,CBLC,ITGB1,CLTC |
Protein Function
SEPT9 has several biochemical functions, for example, GTP binding,GTPase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEPT9 itself. We selected most functions SEPT9 had, and list some proteins which have the same functions with SEPT9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | RAB22A,LGALS6,CDC42L,RAB11A,TUBG2,RAB34A,GUCY1B3,ARL3L1,TUBAL3,SEPT12 |
| protein binding | LNX2,KCNH7,TFDP1,PLK1,RINT1,HTR1B,LINC01588,UBE2D2A,TEKT3,MAGEA2B |
| GTPase activity | RAB3D,RAP2A,IRGE4,NKIRAS1,MFN1,EFTUD2,MX1,RAB37,RAB7L1,GNAI3 |
Interacting Protein
SEPT9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEPT9 here. Most of them are supplied by our site. Hope this information will be useful for your research of SEPT9.
SEPT6;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;IKBKG;DDA1;TRAF6;STK11;pi3p;Sept7;ssdna_dtdc;Calu;PTBP3;FN1
Resources
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References
- Stanbery, L; D'Silva, NJ; et al. High SEPT9_v1 Expression Is Associated with Poor Clinical Outcomes in Head and Neck Squamous Cell Carcinoma. TRANSLATIONAL ONCOLOGY 3:239-245(2010).
- Tachibana, T; Okazaki, E; et al. Rat Monoclonal Antibody Specific for Septin 9. HYBRIDOMA 29:169-171(2010).
