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SENP6

Official Full Name

SUMO1/sentrin specific peptidase 6
Overview

Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339);and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not;result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM;602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from;degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino;acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL;precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins;(Kim et al., 2000 (PubMed 10799485)). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated;substrates (Lima and Reverter, 2008 (PubMed 18799455)).
Synonyms

SENP6; SUMO1/sentrin specific peptidase 6; SUMO1/sentrin specific protease 6; sentrin-specific protease 6; KIAA0797; SUSP1; 2810017C20Rik; SUMO-1-specific protease 1; sentrin/SUMO-specific protease SENP6; SSP1; FLJ11355; FLJ11887; KIAA0389;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SENP6-182H	Recombinant Human SENP6, His-tagged	E.coli	His		Inquiry
Human	SENP6-001H	Recombinant Human SENP6 Protein, His-tagged	E.coli	His	637-1112	Inquiry
Human	SENP6-0893H	Recombinant Human SENP6 Protein (K628-D1112), Tag Free	E.coli	Non	K628-D1112	Inquiry
Human	SENP6-0894H	Recombinant Human SENP6 Protein (K628-D1112), GST tagged	E.coli	GST	K628-D1112	Inquiry
Mouse	SENP6-14882M	Recombinant Mouse SENP6 Protein	Mammalian Cell	His		Inquiry
Mouse	SENP6-8017M	Recombinant Mouse SENP6 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	SENP6-8017M-B	Recombinant Mouse SENP6 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

SENP6 involved in several pathways and played different roles in them. We selected most pathways SENP6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SENP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SENP6 has several biochemical functions, for example, SUMO-specific protease activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SENP6 itself. We selected most functions SENP6 had, and list some proteins which have the same functions with SENP6. You can find most of the proteins on our site.

Function	Related Protein
SUMO-specific protease activity	SENP6;SENP5;SENP3A;SENP3B;SENP1;SENP3
protein binding	SDHB;LSM10;SMCP;AEN;MACROD1;ATF6;ZFP36L1;INO80;TAOK1

SENP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SENP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SENP6.

SP1; SCHIP1; glgB

Research Area

Gibbs-Seymour, I; Oka, Y; et al. Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage. MOLECULAR CELL 57:150-164(2015).

Tosti, E; Katakowski, JA; et al. Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells. GENOME MEDICINE 6:-(2014).