SENP1

  • Official Full Name

    SUMO1/sentrin specific peptidase 1

  • Overview

    This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO);protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also;functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple;transcript variants.

  • Synonyms

    SENP1;SUMO1/sentrin specific peptidase 1;SUMO1/sentrin specific protease 1;sentrin-specific protease 1;sentrin/SUMO-specific protease SENP1;SuPr-2

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Mammalian Cell
  • N/A
  • HEK293
  • His
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
SENP1-2576H Recombinant Human SENP1, His-tagged E.coli Human His 1-331aa
SENP1-686H Active Recombinant Human SENP1, GST-tagged E.coli Human GST
SENP1-14878M Recombinant Mouse SENP1 Protein Mammalian Cell Mouse His
SENP1-180H Recombinant Human SENP1, His-tagged E.coli Human His
SENP1-687H Recombinant Human SENP1, His-tagged E.coli Human His 419-643 a.a.
SENP1-688H Recombinant Human SENP1 Catalytic Domain, His-tagged N/A Human His 415-643 a.a.
SENP1-1975HCL Recombinant Human SENP1 293 Cell Lysate HEK293 Human Non
SENP1-8013M Recombinant Mouse SENP1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
SENP1-8013M-B Recombinant Mouse SENP1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SENP1 involved in several pathways and played different roles in them. We selected most pathways SENP1 participated on our site, such as Metabolism of proteins,Post-translational protein modification,Processing and activation of SUMO, which may be useful for your reference. Also, other proteins which involved in the same pathway with SENP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    SUMOylation RNF2,SCMH1,SMC5,CBX8,PHC2,SENP5,NSMCE1,EID3,SAE1,SMC6
    Post-translational protein modification WDR85,SPON1B,ALG14,NAPG,SMC6,PPP6C,TRAPPC2L,SPON2,MGAT4B,ARSD
    SUMO is proteolytically processed SENP5
    Processing and activation of SUMO SAE1,SENP5,UBA2
    Regulation of Androgen receptor activity APPBP2,TRIM24,NR2C2,NR2C1,KAT7,SRY,HOXB13,SPDEF,SMARCE1,SMARCA2
    Metabolism of proteins HSCB,IGFBP2,PFDN6,EIF5,SUMF2,ARSE,NEU3,KIFC3,CMA1,DPH5

    Protein Function

    SENP1 has several biochemical functions, for example, SUMO-specific protease activity,endopeptidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SENP1 itself. We selected most functions SENP1 had, and list some proteins which have the same functions with SENP1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding CSE1L,MUL1,KRTAP12-1,ESR2,OAS3,CABP1,SPP1,CSTF2T,STARD3,TCOF1
    SUMO-specific protease activity SENP6,SENP3B,SENP3,SENP5,SENP3A
    endopeptidase activity PSMA6A,KLK1B1,ELANE,ADAM10,PSMB11,PSMB6,MMP1,PSMB8F,CTSH,PARL

    Interacting Protein

    SENP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SENP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SENP1.

    SUMO1;SUMO3;ypvA;q8clr7_yerpe

    Resources

    Research Area

    Deubiquitinating Enzymes (DUBs)
    Ubiquitin-like Modifiers (UBLs) and Regulators
    Post-translational Modification of NFkB/IkB

    References

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