SEMA7A
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Official Full Name
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A -
Overview
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. -
Synonyms
SEMA7A;sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A;Semal;CDw108;H-Sema-L;M-Sema-L;2900057C09Rik;semaphorin-7A;sema L;sema K1;H-Sema K1;semaphorin-L;Semaphorin K1;semaphorin-K1
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Zebrafish
- Mammalian cells
- HEK293
- Mammalian Cell
- E.coli
- Yeast
- HEK293T
- Fc
- His
- Non
- His&T7
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
SEMA7A involved in several pathways and played different roles in them. We selected most pathways SEMA7A participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA7A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | SPRED3,SEMA6A,NETO2,SLC14A2,FGF18B,KCNQ3,SEMA3B,NCK1,EFNA5,PPP3CA |
Protein Function
SEMA7A has several biochemical functions, for example, NOT chemorepellent activity,integrin binding,neuropilin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA7A itself. We selected most functions SEMA7A had, and list some proteins which have the same functions with SEMA7A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SARM1,DARS2,PHAX,CDK15,SLC4A1A,SPI1B,MPZL1L,DEAF1,CHMP2A,PKD1L3 |
| integrin binding | ADAM2,COL4A3,ADAM15,TSPAN8,FERMT3,JAM3,TNN,CYR61,LAMB2,S1PR2 |
| neuropilin binding | SEMA3C,SEMA3BL,SEMA3AA,SEMA3E,SEMA3B,SEMA3GA,VEGFA,SEMA3G,SEMA3AB,SEMA3A |
Interacting Protein
SEMA7A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA7A here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA7A.
PLXNC1;aerA;ABL1;FYN;NCK1;GRB2
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