SEC63
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Official Full Name
SEC63 homolog (S. cerevisiae) -
Overview
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. -
Synonyms
SEC63;SEC63 homolog (S. cerevisiae);SEC63 like (S. cerevisiae);translocation protein SEC63 homolog;DNAJC23;ERdj2;PRO2507;SEC63L;SEC 63
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- Pongo Abelii
- Schizosaccharomyces pombe
- Mus musculus
- S.cerevisiae
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- HEK293T
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
SEC63 involved in several pathways and played different roles in them. We selected most pathways SEC63 participated on our site, such as IRE1alpha activates chaperones,Metabolism of proteins,Protein export, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEC63 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | MAPK8B,UBE2D2L,STT3A,HSC70,CUL1A,RNF185,ATXN3,UBE2E2,MARCH6,PPP1R15A |
| Unfolded Protein Response (UPR) | WIPI1,PDIA6,HDGF,YY2,DNAJB9,SERP1,CTDSP2,TPP1,ASNA1,CXXC1 |
| XBP1(S) activates chaperone genes | ASNA1,CXXC1,KDELR3,C19orf10,WIPI1,KLHDC3,TPP1,CTDSP2,YIF1A,DNAJB9 |
| Metabolism of proteins | PFDN6,NSMCE4A,IGFBP2B,DAD1,IGFBP2,ADAMTSL5,CHCHD4,CMA1,MUC5AC,SCFD1 |
| Protein export | ARXES2,secB,ARXES1,SRP19,SRP54A,SRP9,HSPA5,SEC11A,SRP54,SRPR |
| IRE1alpha activates chaperones | PREB,SEC61B,HYOU1,ADD1,HDGF,KLHDC3,C19orf10,FKBP14,CXXC1,CTDSP2 |
Protein Function
SEC63 has several biochemical functions, for example, poly(A) RNA binding,protein binding,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SEC63 itself. We selected most functions SEC63 had, and list some proteins which have the same functions with SEC63. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | UBE2D2A,ERBB4,PPP5C,TRIP6,BNIP3L,NRAP,UNC45A,SRM,RAB35,APBB3 |
| receptor activity | RNF139,NOTCH1A,GRIK3,CNTNAP1,ANPEP,CD226,GRIN3B,TIGIT,ITGB3A,RPA1 |
| poly(A) RNA binding | HDLBP,PTBP2,PPIE,RPS15A,TRMT1,DHX8,MRPS26,DIDO1,HNRNPU,CLNS1A |
Interacting Protein
SEC63 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEC63 here. Most of them are supplied by our site. Hope this information will be useful for your research of SEC63.
Nxn;PTP4A3;MCC;HLA-B;MAGEA6;MDM2;GSTK1;PHLDA3;NXN;cutF;15-deoxy-delta(12,14;Irf1;Bub1b
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