SCMH1
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Official Full Name
sex comb on midleg homolog 1 -
Overview
Polycomb protein SCMH1 is a protein that in humans is encoded by the SCMH1 gene. -
Synonyms
SCMH1;sex comb on midleg homolog 1 (Drosophila);polycomb protein SCMH1;Scml3
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SCMH1-2534H | Recombinant Human SCMH1, GST-tagged | E.coli | Human | GST | C-term-300aa | |
| SCMH1-14750M | Recombinant Mouse SCMH1 Protein | Mammalian Cells | Mouse | His |
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| SCMH1-28619TH | Recombinant Human SCMH1, His-tagged | E.coli | Human | His | 287-591 a.a. |
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| SCMH1-5587Z | Recombinant Zebrafish SCMH1 | Mammalian Cells | Zebrafish | His |
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| SCMH1-2033HCL | Recombinant Human SCMH1 293 Cell Lysate | HEK293 | Human | Non |
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| SCMH1-7935M | Recombinant Mouse SCMH1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| SCMH1-7935M-B | Recombinant Mouse SCMH1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SCMH1 involved in several pathways and played different roles in them. We selected most pathways SCMH1 participated on our site, such as Cellular Senescence,Cellular responses to stress,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCMH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | TRAPPC5,MTX1,B3GNT8,CMA1,PCSK2,OTOP2,NAPAA,DPH5,SEC23IP,MUC12 |
| SUMOylation | NSMCE1,RING1,SMC5,UBA2,CBX8,RNF2,PHC3,SENP1,NSMCE2,PHC1 |
| Cellular Senescence | CDK6,CDKN2C,RBBP7,MINK1,HMGA1,RAD50,BMI1B,HIST1H1C,HIST1H1D,EED |
| Oxidative Stress Induced Senescence | CBX8A,CBX6A,RNF2,PHC2,SUZ12B,KDM6B,EED,RING1,SUZ12,PHC1 |
| SUMO E3 ligases SUMOylate target proteins | SMC6,NSMCE1,CBX8,PHC2,NSMCE4A,NSMCE2,RNF2,RING1,PHC1,EID3 |
| Post-translational protein modification | ST8SIA3,NSMCE1,GNE,DPH5,MPDU1,GALNT13,SPON2,A4GNT,PPP6C,MUCL1 |
| Cellular responses to stress | ACD,HIST1H1E,AMBRA1A,CBX8A,TERF1,WDR45,C11orf73,TXN,LAMTOR2,HIST2H3C |
| SUMOylation of DNA damage response and repair proteins | RNF2,SMC6,NSMCE2,CBX8,PHC2,PHC3,EID3,NSMCE4A,SMC5,NSMCE1 |
Protein Function
SCMH1 has several biochemical functions, for example, DNA binding,protein binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCMH1 itself. We selected most functions SCMH1 had, and list some proteins which have the same functions with SCMH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | IKBKE,NME3,MSH4,CTSD,GTF3C5,SYT11,HIST1H4B,BRPF3,CCL7,CD1A |
| DNA binding | KLF7,E4F1,ORC6L,HIST2H2L,CIC,FOXC1B,UBN2A,CR2,AHR2,EVX2 |
| transcription factor activity, sequence-specific DNA binding | TEAD1,TADA3,NPAS2,UBN2,PRRX2,HOXC6A,FOXI1,POU4F1,ZNF287,HMGA1B |
Interacting Protein
SCMH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCMH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SCMH1.
MAGEA12;UBQLN1;UBQLN1;LYPLA2;TMEM11;HK1;TOB1;GRINL1A;PHC2;UBQLN4;MOB4;Bmi1;Cbx2
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References
- Takada, Y; Isono, KI; et al. Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes. DEVELOPMENT 134:579-590(2007).
- Sathyamurthy, A; Allen, MD; et al. Crystal structure of the malignant brain tumor (MBT) repeats in Sex Comb on Midleg-like 2 (SCML2). JOURNAL OF BIOLOGICAL CHEMISTRY 278:46968-46973(2003).
