SCD1
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Official Full Name
stearoyl-Coenzyme A desaturase 1 -
Synonyms
SCD1;stearoyl-Coenzyme A desaturase 1;acyl-CoA desaturase 1;STOMATAL CYTOKINESIS-DEFECTIVE 1;asebia;delta-9 desaturase 1;delta(9)-desaturase 1;fatty acid desaturase 1;stearoyl-CoA desaturase 1;ab;Scd;Scd-1;AA589638;AI265570
Recombinant Proteins
- Mouse
- Rat
- Mus musculus
- Mammalian Cells
- E.Coli/Yeast
- E.coli
- HEK293
- His
- Myc
- Avi
- Fc
Involved Pathway
SCD1 involved in several pathways and played different roles in them. We selected most pathways SCD1 participated on our site, such as Biosynthesis of unsaturated fatty acids,Fatty acid metabolism,PPAR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AMPK signaling pathway | PCK2,PRKAA1,PIK3R5,PPP2R2A,PIK3R1,FASN,CAB39,IRS4,FBP2,G6PC |
| Fatty acid metabolism | HADHA,ACADSB,ACADM,MECR,HADHB,CPT2,ACSL1B,ELOVL5,CPT1A,PTPLAD2 |
| Biosynthesis of unsaturated fatty acids | HADHA,HSD17B12,TECR,ACOX3,PTPLAD1,ELOVL5,ACOX1,PECR,ACOT1,ACAA1A |
| PPAR signaling pathway | RXRG,FABP7B,MMP1,RXRA,SLC27A1B,PPARA,RXRBA,SCD5,ACSL3A,RXRGB |
Protein Function
SCD1 has several biochemical functions, for example, iron ion binding,metal ion binding,oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SCD1 itself. We selected most functions SCD1 had, and list some proteins which have the same functions with SCD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| stearoyl-CoA 9-desaturase activity | FADS2,SCD5,SCD,Scd2 |
| iron ion binding | EGLN1,CYP1A,ACO2,CYP2AA7,CYP21A2,CYGB,CYP3C4,CYP2A12,PHF2,HBB-Y |
| metal ion binding | PPM1DA,FRRS1,BMPR1BB,PRKD1,CA15A,HIVEP3,ZBTB12.2,ARHGEF38,SNAI1,TP63 |
| oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water | SCDB,Scd2 |
| palmitoyl-CoA 9-desaturase activity | Scd2 |
| oxidoreductase activity | AOX3L1,HMGCRB,DIO3A,CYP3A5,ALDH9A1A.1,CYP3A4,FADS6,CYP46A1.1,CYP2F2,ALOX5A |
Interacting Protein
SCD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SCD1.
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References
- Samuel, W; Kutty, RK; et al. Fenretinide Induces Ubiquitin-Dependent Proteasomal Degradation of Stearoyl-CoA Desaturase in Human Retinal Pigment Epithelial Cells. JOURNAL OF CELLULAR PHYSIOLOGY 229:1028-1038(2014).
- Ben-David, U; Gan, QF; et al. Selective Elimination of Human Pluripotent Stem Cells by an Oleate Synthesis Inhibitor Discovered in a High-Throughput Screen. CELL STEM CELL 12:167-179(2013).
