SCARF1
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Official Full Name
scavenger receptor class F, member 1 -
Overview
The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells and mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Transcription factors ZNF444/EZF-2 and SP1 are found to be responsible for the regulation of this gene. Five alternatively spliced transcript variants encoding distinct isoforms have been described. -
Synonyms
SCARF1;scavenger receptor class F, member 1;scavenger receptor class F member 1;acetyl LDL receptor;KIAA0149;scavenger receptor expressed by endothelial cells;SREC;endothelial cells scavenger receptor;scavenger receptor expressed by endothelial ce
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SCARF1-14718M | Recombinant Mouse SCARF1 Protein | Mammalian Cell | Mouse | His |
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| SCARF1-7924M | Recombinant Mouse SCARF1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SCARF1-7924M-B | Recombinant Mouse SCARF1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SCARF1 involved in several pathways and played different roles in them. We selected most pathways SCARF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SCARF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SCARF1 has several biochemical functions, for example, low-density lipoprotein particle binding,protein binding,scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SCARF1 itself. We selected most functions SCARF1 had, and list some proteins which have the same functions with SCARF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| scavenger receptor activity | ENDOU,CFI,SCART1,LOXL3B,SCARA5,LOXL3A,TMPRSS3,CD5,LOXL2B,POLR1B |
| protein binding | BCAR3,SIPA1L2,MSR1,GDNF,ALKBH6,IRF4,TRAK1,APC,TCERG1,BLCAP |
| low-density lipoprotein particle binding | ANKRA2,CRP,LDLR,SCARB1,LIPC,THBS1,PCSK9,SORL1,CDH13,COLEC12 |
Interacting Protein
SCARF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCARF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SCARF1.
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References
- Lai, WA; Yeh, YT; et al. Ovarian granulosa cells utilize scavenger receptor SR-BI to evade cellular cholesterol homeostatic control for steroid synthesis. JOURNAL OF LIPID RESEARCH 54:365-378(2013).
- Myles, A; Tuteja, A; et al. Synovial fluid mononuclear cell gene expression profiling suggests dysregulation of innate immune genes in enthesitis-related arthritis patients. RHEUMATOLOGY 51:1785-1789(2012).
