SARS2
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Official Full Name
seryl-tRNA synthetase 2, mitochondrial -
Overview
This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. -
Synonyms
SARS2;seryl-tRNA synthetase 2, mitochondrial;SARSM, serine tRNA ligase, mitochondrial , seryl tRNA synthetase 2;seryl-tRNA synthetase, mitochondrial;FLJ20450;mtSerRS;SARS;serine tRNA ligase 2;mitochondrial;SerRSmt;SERS;SYS;SARSM;Serine tRNA ligase;Serine--tRNA ligase;SerRS;Seryl tRNA synthetase 2;Seryl-tRNA synthetase;Seryl-tRNA(Ser/Sec) synthetase;SYSM_HUMAN;serine-tRNA ligase, mitochondrial;mitochondrial seryl-tRNA synthetase;serine tRNA ligase 2, mitochondrial
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- His&GST
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SARS2-2513H | Recombinant Human SARS2, GST-tagged | E.coli | Human | GST | 169-518aa | |
| SARS2-11396Z | Recombinant Zebrafish SARS2 | Mammalian Cell | Zebrafish | His |
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| SARS2-14678M | Recombinant Mouse SARS2 Protein | Mammalian Cell | Mouse | His |
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| SARS2-2060HCL | Recombinant Human SARS2 293 Cell Lysate | HEK293 | Human | Non |
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| Sars2-2043M | Recombinant Mouse Sars2 Protein, His&GST-tagged | E.coli | Mouse | His&GST | Asn277-Arg578 |
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| SARS2-2673H | Recombinant Human SARS2 Protein, His-tagged | E.coli | Human | His | Leu242-Ser518 |
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| Sars2-5692M | Recombinant Mouse Sars2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| SARS2-7904M | Recombinant Mouse SARS2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SARS2-7904M-B | Recombinant Mouse SARS2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SARS2 involved in several pathways and played different roles in them. We selected most pathways SARS2 participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SARS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aminoacyl-tRNA biosynthesis | DARS,WARS2,HARS2,DARS2,YARS2,SARS,GATC,PARS2,HARS,IARS2 |
Protein Function
SARS2 has several biochemical functions, for example, ATP binding,poly(A) RNA binding,serine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SARS2 itself. We selected most functions SARS2 had, and list some proteins which have the same functions with SARS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ATP13A4,SMARCAL1,ATAD5B,NWD1,KATNA1,PAPSS1,HUNK,GNE,ABCB8,RPS6KB1 |
| serine-tRNA ligase activity | SARS |
| poly(A) RNA binding | UTP11L,SRSF12,PTRF,POLR2A,NUPL2,CNOT4,NQO1,ROCK2,NOL10,SR140 |
Interacting Protein
SARS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SARS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SARS2.
HSP90AB1;DMWD;SQSTM1;TRMT10C;USP44;PUF60;TP53;ICT1;IFI16;SIRT4
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