SAP30

  • Official Full Name

    Sin3A-associated protein, 30kDa

  • Overview

    Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3.

  • Synonyms

    SAP30;Sin3A-associated protein, 30kDa;sin3A associated protein, 30kDa;histone deacetylase complex subunit SAP30;sin3-associated polypeptide p30;30 kDa Sin3-associated polypeptide;Sin3-associated polypeptide, 30kDa;sin3-associated polypeptide, 30 kDa;Sin3 corepressor complex subunit SAP30

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
SAP30-3031H Recombinant Human SAP30 protein, His-tagged E.coli Human His 68 - 197 aa
SAP30-14669M Recombinant Mouse SAP30 Protein Mammalian Cells Mouse His
SAP30-4072R Recombinant Rhesus monkey SAP30 Protein, His-tagged Mammalian Cells Rhesus macaque His
SAP30-1559HCL Recombinant Human SAP30 cell lysate Human Non
SAP30-3889R Recombinant Rhesus Macaque SAP30 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
SAP30-3889R-B Recombinant Rhesus Macaque SAP30 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
SAP30-7899M Recombinant Mouse SAP30 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
SAP30-7899M-B Recombinant Mouse SAP30 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SAP30 involved in several pathways and played different roles in them. We selected most pathways SAP30 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SAP30 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chromatin modifying enzymes HMG20B,KAT8,SAP130,SMARCA4,MORF4L1,PBRM1L,ING3,EED,USP22,KDM6B
    Epigenetic regulation of gene expression SAP30BP,PHF1,RBB4L,CD3EAP,SAP130,SUZ12A,JARID2,DNMT3A,DNMT3L,SUDS3
    Gene Expression ZNF34,WARS2,HIPK1,ADARB1A,ZNF143,PUS1,ZNF473,ZNF561,WDR77,ADAT2
    HDACs deacetylate histones SAP30L,PHF21A,SUDS3,HMG20B,MTA1,MBD3,GATAD2A,CHD4A,ANO9A,BRMS1
    Negative epigenetic regulation of rRNA expression SAP30BP,SAP30L,EFCAB11,SAP130,SIN3B,BAZ2A,DNMT3B,RRP8,TAF1C,TAF1D
    Delta-Notch Signaling Pathway ASCL1,CNTF,ZFPM1,APPA,JAG1,YY1A,CNTN1,TUBB3,SMAD3B,JAG2
    Hedgehog signaling events mediated by Gli proteins CSNK1G2,MTSS1,SIN3B,KIF3A,SPOP,LGALS3,CSNK1G3,IFT88,SAP18
    Chromatin organization VPS72,KDM3A,PADI2,SAP130,RBBP4,KDM1A,KDM4B,PRMT6,PHF2,ARID4A

    Protein Function

    SAP30 has several biochemical functions, for example, DNA binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SAP30 itself. We selected most functions SAP30 had, and list some proteins which have the same functions with SAP30. You can find most of the proteins on our site.

    Function Related Protein
    transcription corepressor activity ATF7IP,SSX5,PFDN5,NFKBIL2,C1QBP,ASXL1,RUNX1T1,E4F1,ID4,RBFOX2
    protein binding NAA38,CRABP2,UNC119B,LEPROT,RBM10,OAZ1,Car8,NUP35,SEC24A,MAD2L1BP
    metal ion binding TMEM129,ZNF444,CACNA2D1,ZFP458,ZFP524,KLF18,ZC3H12A,B3GAT1,HIC1,GTF2E1
    DNA binding NUCB2,FOXO3,HMGA1,HNRPDL,ZNF526,ZFAT,SATB1A,KDM2B,GM14482,GLI4

    Interacting Protein

    SAP30 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SAP30 here. Most of them are supplied by our site. Hope this information will be useful for your research of SAP30.

    HDAC1;HDAC2;SIN3A;NCOR2;CIR1;Max;BRMS1;SAP130;TNRC18;SIN3B;SIN3B;ARID4A;FOXK1;FOXK2;SMC1A

    SAP30 Related Signal Pathway

    Resources

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