S1PR5
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Official Full Name
sphingosine-1-phosphate receptor 5 -
Overview
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors. -
Synonyms
S1PR5;sphingosine-1-phosphate receptor 5;EDG8, endothelial differentiation, sphingolipid G protein coupled receptor, 8;sphingosine 1-phosphate receptor 5;Edg 8;S1P receptor 5;S1P receptor Edg-8;sphingosine 1-phosphate receptor EDG8;sphingosine 1-
Recombinant Proteins
- Human
- Mouse
- Rat
- Mus musculus
- Sus scrofa (Pig)
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli expression system
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
S1PR5 involved in several pathways and played different roles in them. We selected most pathways S1PR5 participated on our site, such as Sphingolipid signaling pathway,Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with S1PR5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | GRIK3,AVPR1A,MC5R,TACR1B,DRD4-RS,GH2,P2RX1,LHB,GHRHR,P2RY11 |
| Sphingolipid signaling pathway | MAP3K5,PRKCA,PPP2R5A,PDPK1,MAP2K1,GNAI2,ASAH2,PPP2R1A,RHOA,PLCB1 |
Protein Function
S1PR5 has several biochemical functions, for example, sphingosine-1-phosphate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by S1PR5 itself. We selected most functions S1PR5 had, and list some proteins which have the same functions with S1PR5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sphingosine-1-phosphate receptor activity | S1PR2,S1PR4,SPHK1,S1PR3,S1PR3A,S1PR5A,SPHK2,S1PR1,GPR6,S1PR5B |
Interacting Protein
S1PR5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S1PR5 here. Most of them are supplied by our site. Hope this information will be useful for your research of S1PR5.
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References
- Takabe, K; Spiegel, S; et al. Export of sphingosine-1-phosphate and cancer progression. JOURNAL OF LIPID RESEARCH 55:1839-1846(2014).
- Wang, CY; Mao, JH; et al. Systemic distribution, Subcellular localization and differential expression of sphingosine-1-phosphate receptors in benign and malignant human tissues. EXPERIMENTAL AND MOLECULAR PATHOLOGY 97:259-265(2014).
