Ryr2
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Official Full Name
ryanodine receptor 2, cardiac
Recombinant Proteins
- Mouse
- Human
- Rat
- Mammalian Cells
- E.coli
- HEK293
- His
- SUMO
- GST
- Avi
- Fc
Involved Pathway
Ryr2 involved in several pathways and played different roles in them. We selected most pathways Ryr2 participated on our site, such as Calcium signaling pathway,cAMP signaling pathway,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ryr2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | PLCE1,TACR3,MYLK,PPIFA,PRKACAB,LHCGR,GNA14,P2RX2,CAMK2B1,GNAL |
| Hypertrophic cardiomyopathy (HCM) | ITGA1,SGCA,ITGB3,SGCD,Itga10&Itgb1,PRKAG1,DES,ITGB8,ACTG1,TGFB3 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ACTG1,CTNNA1,SGCB,CDH2,DES,SGCG,CACNB3,CACNA2D1,DAG1,ITGB4 |
| cAMP signaling pathway | NPR1,CALM1,MAP2K1,CREB3L2,MAPK9,NFATC1,HCN4,GNAI2,VAV2,FFAR2 |
| Oxytocin signaling pathway | MYL6,CACNB1,PPP1CB,GNAO1,PLA2G4F,PIK3CD,CAMKK1,PIK3R2,PRKCB,PPP1R12A |
| Dilated cardiomyopathy | ACTG1,MYL2,CACNG6,TGFB2,PRKACB,TNNI3,SGCD,ACTB,DES,TGFB1 |
| Circadian entrainment | GUCY1A3,GNB4,MAPK1,GNAS,MTNR1A,PRKACA,PRKCB,GNG8,PRKG1,PRKCA |
| Cardiac muscle contraction | COX7A2,VMHCL,TNNC1B,CACNG6A,COX7A1,CACNB2A,TNNC1,UQCR10,VMHC,COX5B2 |
| Adrenergic signaling in cardiomyocytes | CALM4,VMHC,MAPK1,CACNG8,PRKACAB,GNA11A,PIK3R3B,AGTR2,MAPK14A,TPM1 |
Protein Function
Ryr2 has several biochemical functions, for example, calcium channel activity,calcium ion binding,calcium-induced calcium release activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ryr2 itself. We selected most functions Ryr2 had, and list some proteins which have the same functions with Ryr2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase A regulatory subunit binding | KCNQ1,PRKACA,AKAP8,AKAP6,C2orf88,AKAP7,AKAP9,ARFGEF2,EZR,AKAP1 |
| calcium-release channel activity | JPH3,TRPV1,JPH2,RASA3,RYR1,RYR3 |
| ryanodine-sensitive calcium-release channel activity | RYR3,RYR1,RYR1B |
| protein self-association | CNTN2,TRP53,SYP,AGTR1B,ZSWIM2,SVIP,PROSAPIP1,AGA,DYRK1A,AGXT |
| calmodulin binding | CAMK2B,CAMSAP1,MYH1E,TJP1,CAMK4,PPP3CB,SMTNL1,MYH7,MKNK1,CAMK2D2 |
| calcium channel activity | RYR1,TRPC7B,P2RX1,TRPV4,TRPV5,TRPC2B,CACFD1,CUL5,CACNG2A,PANX1 |
| ion channel binding | FHL1,SUMO1,AKAP9,CIB1,KCNAB1,CAV3,SCN5A,CTNNB1,KCND3,BAK1 |
| protein binding | ATRIP,COBL,NR3C1,GMCL1,HTN1,CIB4,FRS3,STK24,SFTPC,CGA |
| intracellular ligand-gated calcium channel activity | ITPR3,TRPA1,AKR1C1,ITPR1 |
Interacting Protein
Ryr2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ryr2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ryr2.
FKBP1B;MDM2;PRKACA;FKBP1A;vgrG7;q81z75_bacan;SMAD5;ALB;CFTR;AKAP6
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References
- Moore, CJ; Shao, CH; et al. Malondialdehyde and 4-hydroxynonenal adducts are not formed on cardiac ryanodine receptor (RyR2) and sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2) in diabetes. MOLECULAR AND CELLULAR BIOCHEMISTRY 376:121-135(2013).
- Qiu, AW; Yang, Q; et al. Interleukin-6 prevents NMDA-induced neuronal death via Gp130 signaling-dependent IP3R inhibition. NEUROENDOCRINOLOGY LETTERS 34:529-538(2013).
