Ryr2

  • Official Full Name

    ryanodine receptor 2, cardiac

Recombinant Proteins

  • Mouse
  • Human
  • Rat
  • Mammalian Cell
  • E.coli
  • HEK293
  • His
  • His&Fc&Avi

    Involved Pathway

    Ryr2 involved in several pathways and played different roles in them. We selected most pathways Ryr2 participated on our site, such as Calcium signaling pathway,cAMP signaling pathway,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ryr2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ATP2A2,CACNG2,CACNA2D1,DSP,ACTG1,CACNG8,SGCA,AASS,ACTN2,CACNA2D3
    Circadian entrainment GNG5,PRKACA,GNG11,KCNJ6,PRKACG,NOS1AP,CALM4,GNGT1,PRKG1,PLCB2
    Cardiac muscle contraction COX6A1,COX7C,CACNG3,VMHCL,CACNA2D3,COX8A,ATP1B3,TPM3,COX5B,MYL3
    cAMP signaling pathway GRIA2,ATP1A1,PTCH1,GRIN3B,ORAI1,GABBR1,GRIN2A,VAV2,ATP1B1,HCN4
    Pancreatic secretion ATP1A2,RAP1A,PLA2G3,TPCN2,ATP2A3,FXYD2,Slc4a2,CLCA4,CD38,RHOA
    Oxytocin signaling pathway PPP3CC,MAP2K2,PIK3R5,CAMK2B,KRAS,CACNB1,CACNA2D3,PIK3R3,ACTG1,PPP1CA
    Calcium signaling pathway PRKACA,HTR7,DRD1A,TMEM8C,CAMK4,ADORA2AA,AGTR1,CALM2,Adcy4,MYLK3
    Adrenergic signaling in cardiomyocytes ATP1B3,PIK3R3B,TPM4A,PPP2R5EB,CACNG3,CAMK2B,ATP2A2,TNNC1,CAMK2D,SCN1B
    Insulin secretion SLC2A2,VAMP2,GPR119,KCNMB4,KCNMB1,GCG,GNAS,PRKCB,STX1A,ATP1A2

    Protein Function

    Ryr2 has several biochemical functions, for example, calcium channel activity,calcium ion binding,calcium-induced calcium release activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ryr2 itself. We selected most functions Ryr2 had, and list some proteins which have the same functions with Ryr2. You can find most of the proteins on our site.

    Function Related Protein
    calcium channel activity GRIN3A,SLC24A1,TRPM1,TRPC5A,CACNA1SB,CACNA1C,CHRNA9,AKR1C1,P2RX1,ORAI1B
    enzyme binding PPP1R3B,APOA1,TSPAN5,PLCB1,UGT1A1,APBA3,TRP53,DYM,EGLN1,RXRA
    identical protein binding ZNF703,GOT1,NOL3,PFKFB1,CALHM1,KLHL7,UBE2G2,ECI1,DHX8,RBM10
    ryanodine-sensitive calcium-release channel activity RYR3,RYR1,RYR1B
    protein binding CTNNA2,SEC22A,RRS1,THAP3,TCTN2,SFRS9,DNAL4,DDX5,RPS6KA2,MSN
    protein kinase A catalytic subunit binding PRKAR1A,GSK3B,EZR,GSK3A,PRKAR1B,PRKAR2B,KCNQ1,PRKAR2A,CSK,PKIA
    intracellular ligand-gated calcium channel activity AKR1C1,ITPR1,ITPR3,TRPA1
    calcium ion binding EGF,CALR,MYL6B,CANT1B,PCDHGA11,SMOC1,TESCB,ICN,ANXA4,SNCA
    ion channel binding DLG1,AKAP6,DIAP1,RANGRF,CAV1,KCNQ1,PRKCSH,NOS1,SRI,TRAPPC2

    Interacting Protein

    Ryr2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ryr2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ryr2.

    FKBP1B;MDM2;PRKACA;FKBP1A;vgrG7;q81z75_bacan;SMAD5;ALB;CFTR;AKAP6

    Resources

    References

    • Moore, CJ; Shao, CH; et al. Malondialdehyde and 4-hydroxynonenal adducts are not formed on cardiac ryanodine receptor (RyR2) and sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2) in diabetes. MOLECULAR AND CELLULAR BIOCHEMISTRY 376:121-135(2013).
    • Qiu, AW; Yang, Q; et al. Interleukin-6 prevents NMDA-induced neuronal death via Gp130 signaling-dependent IP3R inhibition. NEUROENDOCRINOLOGY LETTERS 34:529-538(2013).

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