RYR1

  • Official Full Name

    ryanodine receptor 1 (skeletal)

  • Overview

    Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is a protein found primarily in skeletal muscle. In humans, it is encoded by the RYR1 gene.

  • Synonyms

    RYR1;ryanodine receptor 1 (skeletal);ryanodine receptor 1;skeletal muscle calcium release channel;skeletal muscle ryanodine receptor;skeletal muscle-type ryanodine receptor;type 1 ryanodine receptor;RYR-1

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • GST
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
RYR1-357H Recombinant Human RYR1 Mammalian Cells Human His
RYR1-2037H Recombinant Human RYR1 Protein, His&GST-tagged E.coli Human GST&His His97-Cys392
Ryr1-2038R Recombinant Rat Ryr1 Protein, His-tagged E.coli Rat His His99-Cys394
Ryr1-2669M Recombinant Mouse Ryr1 Protein, His&GST-tagged E.coli Mouse GST&His His99-Cys394
RYR1-301225H Recombinant Human RYR1 protein, GST-tagged E.coli Human GST Gly4942-Ser5038
RYR1-4018H Recombinant Human RYR1 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
RYR1-4018H-B Recombinant Human RYR1 Protein Pre-coupled Magnetic Beads HEK293 Human
RYR1-6742H Recombinant Human RYR1 protein, GST-tagged E.coli Human GST
RYR1-789H Recombinant Human RYR1 Protein (1-534 aa), His-tagged E.coli Human His 1-534 aa
RYR1-790H Recombinant Human RYR1 protein (Skeletal), His-tagged E.coli Human His His97-Cys392

    Involved Pathway

    RYR1 involved in several pathways and played different roles in them. We selected most pathways RYR1 participated on our site, such as Calcium signaling pathway,Circadian entrainment,Long-term depression, which may be useful for your reference. Also, other proteins which involved in the same pathway with RYR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway ATP2A2B,PPP3R1,CAMK2G1,GRIN1A,OXTR,CALM1,GRIN2C,ORAI1,P2RX1,PHKG1B
    Circadian entrainment PRKG1,GNG7,GNG12,GNG3,PRKCA,ITPR3,PRKG2,ADCYAP1R1,NOS1,KCNJ5
    Long-term depression ITPR1,GNA12,MAP2K2,NOS1,ITPR3,PPP2CA,GUCY1A3,PPP1R17,GNA13,PLCB3
    Oxytocin signaling pathway Adcy4,SRC,CACNA2D3,MYLK4,PIK3CD,MAPK1,NFATC3,CACNA2D2,OXTR,CACNB4

    Protein Function

    RYR1 has several biochemical functions, for example, calcium channel activity,calcium-release channel activity,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RYR1 itself. We selected most functions RYR1 had, and list some proteins which have the same functions with RYR1. You can find most of the proteins on our site.

    Function Related Protein
    ryanodine-sensitive calcium-release channel activity RYR2,RYR1B,RYR3
    calmodulin binding DAPK1,MYO9B,DCX,UPF3B,CAMKVB,GAP43,PHKG1A,TRPV4,GRIN1,PDE1A
    protease binding Serpina1c,SELL,INSL3,CCDC71L,SERPINB4,UBC,Cstb,TYSND1,PANX1,FLOT1
    protein binding MPLKIP,ALDH3A1,FIGNL1,LAIR1,DNAL4,TAL2,ARF4,DCDC2,SFRP5,TAF1C
    calcium-release channel activity RYR3,RASA3,JPH2,JPH3,RYR2,TRPV1
    calcium channel activity TRPC5,CACNG8A,UBXN6,CACNA1SA,TRPN1,TRPV6,CUL5,P2RX1,CACNA1C,GRIN2A
    voltage-gated calcium channel activity OPRM1,CACNA1D,CACNG1,NCS1,CACNB4B,CACNG6,CACNB1,CACNG2A,CACNG7,CACNG8

    Interacting Protein

    RYR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RYR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RYR1.

    MYOM2;PPP1CA;PPP2CA;NCK1;PLCG1;GRB2;TULP3;PDLIM3;TTN;TF

    Resources

    References

    • Vukcevic, M; Zorzato, F; et al. Gain of function in the immune system caused by a ryanodine receptor 1 mutation. JOURNAL OF CELL SCIENCE 126:3485-3492(2013).
    • Thakur, P; Dadsetan, S; et al. Bidirectional Coupling between Ryanodine Receptors and Ca2+ Release-activated Ca2+ (CRAC) Channel Machinery Sustains Store-operated Ca2+ Entry in Human T Lymphocytes. JOURNAL OF BIOLOGICAL CHEMISTRY 287:37233-37244(2012).

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    Q&As

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    more details about this recombinant protein, what fragment is it? I am looking for the fragment aa 799-1175. It must be used in western blot 09/20/2024

    Cat#RYR1-4018H does include a.a.799-1175, we can custom produce this domain for you. Please find below the pricing information for this item.

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