RTEL1
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Official Full Name
regulator of telomere elongation helicase 1 -
Overview
In mice, inactivation of the Rtel (regulator of telomere length) gene has been shown to cause chromosome breaks, fusions, and telomere loss. In addition, Rtel is required for telomere elongation. Therefore, the mouse Rtel gene regulates chromosome stability and telomere length. This gene is the human ortholog of the mouse Rtel gene, so its protein product may play similar roles in humans. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, decoy (TNFRSF6B), generates a non-coding transcript. Multiple transcript variants encoding different isoforms have been described for this gene. -
Synonyms
RTEL1;regulator of telomere elongation helicase 1;C20orf41, chromosome 20 open reading frame 41;bK3184A7.3;DKFZP434C013;KIAA1088;NHL;RTEL;C20orf41;Chromosome 20 open reading frame 41;Novel helicase like;Regulator of telomere length;RP4-583P15.2;OTTHUMP00000031577;OTTHUMP00000184892;OTTHUMP00000221856
Recombinant Proteins
- Mouse
- Zebrafish
- Rat
- Human
- Mammalian Cells
- HEK293
- His
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RTEL1-14562M | Recombinant Mouse RTEL1 Protein | Mammalian Cells | Mouse | His |
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| RTEL1-2106Z | Recombinant Zebrafish RTEL1 | Mammalian Cells | Zebrafish | His |
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| RTEL1-5191R | Recombinant Rat RTEL1 Protein | Mammalian Cells | Rat | His |
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| RTEL1-15HCL | Recombinant Human RTEL1 Over-expression Lysate, C-Myc/DDK tagged | HEK293 | Human | Myc&DDK |
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| RTEL1-4850R | Recombinant Rat RTEL1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| RTEL1-4850R-B | Recombinant Rat RTEL1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| RTEL1-7837M | Recombinant Mouse RTEL1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| RTEL1-7837M-B | Recombinant Mouse RTEL1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RTEL1 involved in several pathways and played different roles in them. We selected most pathways RTEL1 participated on our site, such as DNA Double-Strand Break Repair,DNA Repair,HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), which may be useful for your reference. Also, other proteins which involved in the same pathway with RTEL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) | THRSP,RHNO1,BABAM1,TOPBP1,HUS1,PPP4CB,TIMELESS,FAM175A,BRCC3,BRE |
| DNA Double-Strand Break Repair | RAD9B,RAD17,RAD9A,SMARCA5,RNF4,KDM4B,PAXIP1,KIAA0146,GEN1,RBBP8 |
| Resolution of D-Loop Structures | RAD51AP1,GEN1,EME2,KIAA0146 |
| HDR through Homologous Recombination (HRR) | WRN,KIAA0146,RHNO1,EME1,RAD9B,RAD9,RAD51AP1,FUZ,EME2,TOPBP1 |
| DNA Repair | POLD3,KIAA0146,MGMT,RAD9,APITD1,TOPBP1,YY1,DCLRE1A,INO80,BRE |
| Homology Directed Repair | RAD51AP1,PPP4CA,WRN,RHNO1,PPP4CB,KIAA0146,EME1,TOPBP1,TIPIN,EME2 |
Protein Function
RTEL1 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,ATP binding,ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RTEL1 itself. We selected most functions RTEL1 had, and list some proteins which have the same functions with RTEL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrolase activity | NUDT6,CDC14AA,PTPN11A,PRSS30,MMP14A,TMPRSS11G,REXO4,FAM105B,METAP2A,SMG6 |
| ATP binding | TSSK2,NAV2,CDK3,MAPK14B,CDK10,SMARCA2,P2RY2,RIMKLA,STK33,PRKY |
| helicase activity | ACTG2,DDX11,SNRNP200,DDX39,DDX6,UPF1,HLTF,TDRD9,BAT1,BLM |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | BLM,CHD4A |
| ATP-dependent DNA helicase activity | G3BP1,DDX11,XRCC6,BLM,GTF2H4,RUVBL2,DHX9,XRCC5,CHD4,BRIP1 |
| DNA binding | TEAD4,SOX2,SP8B,LASS5,BRPF1,ZFP11,RORAA,RORCB,ZNF764,MESP1 |
| 4 iron, 4 sulfur cluster binding | ISCA1,MUTYH,PPAT,ISCU,POLA1,POLE,DNA2,MOCS1,NDUFS2,ETFDH |
| nucleic acid binding | ZFP292,KLF18,SRSF6A,ZNF644A,PRDM12,POGZA,ZCCHC4,ZCCHC12,SCRT1A,SALL1A |
| ATP-dependent helicase activity | CHD4A,RECQL5,ERCC6L2,BLM,CHD6,DHX37,DHX36,TTF2,SNRNP200 |
Interacting Protein
RTEL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RTEL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RTEL1.
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References
- Pei, SJ; Zhao, F; et al. Association between regulator of telomere elongation helicase 1 polymorphism and susceptibility to glioma. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8:690-697(2015).
- Recker, J; Knoll, A; et al. The Arabidopsis thaliana Homolog of the Helicase RTEL1 Plays Multiple Roles in Preserving Genome Stability. PLANT CELL 26:4889-4902(2014).
