RRM2B
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Official Full Name
ribonucleotide reductase M2 B (TP53 inducible) -
Overview
This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010] -
Synonyms
RRM2B;ribonucleotide reductase M2 B (TP53 inducible);P53R2;MTDPS8A;MTDPS8B;ribonucleoside-diphosphate reductase subunit M2 B;TP53-inducible ribonucleotide reductase M2 B;p53-inducible ribonucleotide reductase small subunit 2 homolog;p53-inducible ribonucleotide reductase small subunit 2-like protein;p53-inducible ribonucleotide reductase small subunit 2 short form beta
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- DDK&Myc
- Avi&Fc&His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RRM2B-2446H | Recombinant Human RRM2B, GST-tagged | E.coli | Human | GST | 1-350aa | |
| RRM2B-2550H | Recombinant Full Length Human RRM2B, His tagged | E.coli | Human | His | Full L. 1-351 a.a. | |
| RRM2B-14526M | Recombinant Mouse RRM2B Protein | Mammalian Cells | Mouse | His |
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| RRM2B-1653Z | Recombinant Zebrafish RRM2B | Mammalian Cells | Zebrafish | His |
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| RRM2B-1963H | Recombinant Human RRM2B Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| RRM2B-2847H | Recombinant Human RRM2B protein(Met1-Phe351), His-tagged | E.coli | Human | His | Met1-Phe351 |
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| RRM2B-4558H | Recombinant Full Length Human RRM2B protein, GST-tagged | E.coli | Human | GST | Full L. 1-351aa |
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| Rrm2b-5628M | Recombinant Mouse Rrm2b Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| RRM2B-7815M | Recombinant Mouse RRM2B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| RRM2B-7815M-B | Recombinant Mouse RRM2B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RRM2B involved in several pathways and played different roles in them. We selected most pathways RRM2B participated on our site, such as Purine metabolism,Pyrimidine metabolism,Glutathione metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with RRM2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | CTH,PAFAH1B2,PRPS1L1,MAN1A,DNMT4,HMGCS1,CYP26C1,BCO1L,HAO1,NDST2 |
| p signaling pathway | ATM,CDK1,GADD45B,CCNG2,APAF1,PERP,PMAIP1,PTENB,CASP8,TNFRSF10B |
| Purine metabolism | POLR2F,ADSL,PDE5AB,PNP5B,URAH,PGM2,POLR3GL,TM9SF1,PDE10A,NT5C1B-RDH14 |
| Glutathione metabolism | GSS,GPX4A,GSTM6,GSTT2B,GPX3,GSTM2,GGCTA,GPX5,GSTA1,GSTA3 |
| Pyrimidine metabolism | TYMS,NT5C2B,NT5C3L,NT5M,NME2A,TXNRD2,DPYS,PROZA,POLR2J,UCK2 |
Protein Function
RRM2B has several biochemical functions, for example, metal ion binding,protein binding,ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by RRM2B itself. We selected most functions RRM2B had, and list some proteins which have the same functions with RRM2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | RRM2,RRM1 |
| metal ion binding | ZNF333,ZFP768,AGAP1,PLA2G4F,ZNF593,ZNF326,WDFY3,PRIM1,CFI,FYCO1 |
| protein binding | UBLCP1,THOC4,THBD,OLFM1,SH3RF2,PFDN4,TAF3,CLNS1A,HIST3H3,SH2D1B |
Interacting Protein
RRM2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RRM2B here. Most of them are supplied by our site. Hope this information will be useful for your research of RRM2B.
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