RPSA
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Official Full Name
ribosomal protein SA -
Overview
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. -
Synonyms
RPSA;ribosomal protein SA;laminin receptor 1 (67kD, ribosomal protein SA) , LAMR1;40S ribosomal protein SA;37LRP;LRP;p40;SA;34/67 kDa laminin receptor;37 kDa laminin receptor precursor;37/67 kDa laminin receptor;67 kDa laminin receptor;67LR;Colon carcinoma laminin binding protein;Colon carcinoma laminin-binding protein;LAMBR;Laminin Receptor 1;Laminin-binding protein precursor p40;LAMR 1;LamR;LAMR1;LBP/p40;LRP/LR;Multidrug resistance associated protein MGr1 Ag;Multidrug resistance associated protein MGr1Ag;Multidrug resistance-associated protein MGr1-Ag;NEM/1CHD4;RSSA_HUMAN;37 kDa laminin receptor;laminin binding protein;67kD, ribosomal protein SA;laminin receptor 1 (67kD,;LBP
Recombinant Proteins
- Human
- Zebrafish
- Bacillus subtilis
- Mouse
- Chicken
- Rhesus macaque
- Rat
- Pig
- E.coli
- Mammalian Cells
- E.Coli/Yeast
- Wheat Germ
- HEK293
- Yeast
- Insect Cells
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
- His&Myc
Involved Pathway
RPSA involved in several pathways and played different roles in them. We selected most pathways RPSA participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPSA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome | RPL24,MRPL21,RPS14,RPL14,RPL4,RPS10-NUDT3,MRPL16,RPS17,UBA52,RPL36AL |
Protein Function
RPSA has several biochemical functions, for example, laminin binding,laminin receptor activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPSA itself. We selected most functions RPSA had, and list some proteins which have the same functions with RPSA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ribosome binding | ETF1,EIF5A2,NAA16,EIF6,SBDS,C12orf65,ABCF1,EIF5A,MTRF1L,HSPA5 |
| structural constituent of ribosome | RPL39,RPLP2L,RPS27L,RPL8,MRPL36,RPLP0,RPL34,RPS13,MRPS17,RPL11 |
| laminin binding | TINAGL1,LGALS2A,ITGA9,LRRC15,NCL,ITGB1,ADAM9,LGALS3,LYPD5,NID1 |
| protein binding | NECAB3,CKS1B,KDRL,BAI2,CHPF,OAS2,E2F7,HHLA3,TMEM93,SENP1 |
| poly(A) RNA binding | SEC63,STXBP1,BYSL,MBNL1,PTBP2,TRMT10C,SNRNP40,C9orf114,WDR6,ZFC3H1 |
| virus receptor activity | TFRC,SERPINB4,PVRL4,MOG,CD209,ACE2,ITGB6,DAG1,HLA-DRB1,AXL |
| laminin receptor activity | BCAM |
Interacting Protein
RPSA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPSA here. Most of them are supplied by our site. Hope this information will be useful for your research of RPSA.
KARS;TINF2;CALM1;PCNA;ACTB;DCTN6;HSPB1;TFAP2A;PROS1;SLC2A5;ABCD1;ACADVL;RPS21;HBG2
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References
- Zidane, N; Ould-Abeih, MB; et al. The folded and disordered domains of human ribosomal protein SA have both idiosyncratic and shared functions as membrane receptors. BIOSCIENCE REPORTS 33:113-124(2013).
- Ould-Abeih, MB; Petit-Topin, I; et al. Multiple Folding States and Disorder of Ribosomal Protein SA, a Membrane Receptor for Laminin, Anticarcinogens, and Pathogens. BIOCHEMISTRY 51:4807-4821(2012).
