RPS6KB2
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Official Full Name
ribosomal protein S6 kinase, 70kDa, polypeptide 2 -
Overview
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. -
Synonyms
RPS6KB2;ribosomal protein S6 kinase, 70kDa, polypeptide 2;ribosomal protein S6 kinase, 70kD, polypeptide 2;ribosomal protein S6 kinase beta-2;KLS;P70 BETA;p70S6Kb;STK14B;P70S6K2;S6K-beta;p70 S6KB;p70-S6K 2;S6K-beta-2;p70 S6K-beta;p70 S6 kina
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- Sf9 Cells
- HEK293
- Rabbit
- Sf21 Cells
- His
- MBP
- GST
- Non
- Avi
- Fc
- Flag
- DDK
- Myc
Involved Pathway
RPS6KB2 involved in several pathways and played different roles in them. We selected most pathways RPS6KB2 participated on our site, such as ErbB signaling pathway,HIF- signaling pathway,mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIF- signaling pathway | PDK1,HK1,PGK1,PIK3R5,SERPINE1,PIK3CB,PLCG2,VEGFA,LDHA,PIK3R3 |
| Insulin signaling pathway | HK3,FBP1,SOCS2,PRKACBA,PIK3CA,TRIP10A,SHC2,FBP1A,MAP2K1,INS2 |
| mTOR signaling pathway | RPS6KA2,TSC1,PIK3R3A,RICTOR,EIF4EA,RPS6,AKT1S1,PRKCG,PTENA,PTENB |
| TGF-beta signaling pathway | TGFBR1A,ID2B,INHBA,INHBE,RHOA,LTBP1,SPAW,BMP2,RPS6KB1,BMP7A |
| Choline metabolism in cancer | PCYT1A,TAE1,EGF,PIK3R2,KRAS,WASF1,Pdgfa&Pdgfb,PIP5K1C,MTOR,RAC1 |
| AMPK signaling pathway | HMGCR,GYS1,Scd1,INS2,CRTC2,CREB5,ULK1,CREB3,IRS4,TSC1 |
| Acute myeloid leukemia | KRAS,TCF7,NRAS,PIK3R2,ZBTB16,PIK3CB,AKT3,CHUK,RELA,PIK3CG |
| Insulin resistance | PRKAG2A,RPS6KA3,PPARGC1A,IL6,PPARGC1B,FOXO1,GFPT1,G6PC,PRKCE,PPP1R3C |
| Proteoglycans in cancer | ERBB4,MAP2K2,ROCK1,TLR2,MRAS,RDX,HPSE2,PTCH1,MAPK1,TRP53 |
Protein Function
RPS6KB2 has several biochemical functions, for example, ATP binding,peptide binding,protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KB2 itself. We selected most functions RPS6KB2 had, and list some proteins which have the same functions with RPS6KB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | BRAF,STK11,TBK1,AURKB,TRIOA,ULK4,ATM,PAK1,MAPK13,ARAF |
| ATP binding | NSF,PIK3C2B,ACVR2AA,UBE2G1B,TBK1,HELQ,FAM120B,DYRK2,UBA7,DYNC1LI1 |
| peptide binding | IDE,AVPR1B,OXTR,QRFPR,TPP1,AVPR1A,CSNK1D,GPR37,LNPEP,NPFFR1L3 |
| protein kinase activity | CDK14,PRPF4BB,EPHA4A,NEK1,TBK1,MAP4K6,RIPK1L,RIPK4,RPS6KA3A,KITB |
| ribosomal protein S6 kinase activity | RPS6KA6,ALPK2,RPS6KB1B,RPS6KA3,RPS6KA1,RPS6KA3B,RPS6KB1,RPS6KA2,RPS6KA4,RPS6KA3A |
Interacting Protein
RPS6KB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KB2.
RPS6;CSNK2B;SRPK1;COASY;ATP5A1;MAPK8IP2;SNW1;CDC5L;EEF2K
RPS6KB2 Related Signal Pathway
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