RPL7

  • Official Full Name

    ribosomal protein L7

  • Overview

    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

  • Synonyms

    RPL7;ribosomal protein L7;60S ribosomal protein L7;humL7 1;L7;RL7_HUMAN;RPL 7;Rpl7a;Surf 3;OTTHUMP00000166002;OTTHUMP00000166003;OTTHUMP00000166004;OTTHUMP00000166005;humL7-1

Recombinant Proteins

  • Zebrafish
  • Mouse
  • Chicken
  • Human
  • Cynomolgus
  • Mammalian Cell
  • E.coli
  • HEK293
  • His
  • N-His&C-Myc
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
RPL7-12709Z Recombinant Zebrafish RPL7 Mammalian Cell Zebrafish His
RPL7-14447M Recombinant Mouse RPL7 Protein Mammalian Cell Mouse His
RPL7-1489C Recombinant Chicken RPL7 Mammalian Cell Chicken His
RPL7-31336TH Recombinant Human RPL7, His-tagged E.coli Human His 17-248 a.a.
RPL7-882C Recombinant Cynomolgus RPL7 Protein, His-tagged Mammalian Cell Cynomolgus His
RPL7-4447M Recombinant Mouse RPL7 protein(1-270aa), His&Myc-tagged E.coli Mouse N-His&C-Myc 1-270aa
RPL7-625C Recombinant Cynomolgus Monkey RPL7 Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus His&Fc&Avi
RPL7-625C-B Recombinant Cynomolgus Monkey RPL7 Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus
RPL7-7751M Recombinant Mouse RPL7 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
RPL7-7751M-B Recombinant Mouse RPL7 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    RPL7 involved in several pathways and played different roles in them. We selected most pathways RPL7 participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPL7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ribosome RPS26L,RPL11,FAUA,MRPS21,RPL7A,RPL23,RPLP2,MRPS11,MRPL34,RPL36A-HNRNPH2

    Protein Function

    RPL7 has several biochemical functions, for example, DNA binding,RNA binding,mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPL7 itself. We selected most functions RPL7 had, and list some proteins which have the same functions with RPL7. You can find most of the proteins on our site.

    Function Related Protein
    protein binding CCPG1,CPSF4,LRRC3,ZBTB16,KRT18,PEX6,PSMC4,CSRNP2,PSMA3,PRKAB2
    mRNA binding PTBP2,DXO,NANOS2,PCF11,TYMS,TSN,IGF2BP1,CSTF3,MRPL13,RBFOX3
    RNA binding C1D,NOL3,AGO1,ZFP385C,SCAF8,UPF3A,MCTS2,RBM44,IMPDH1,HBP1
    DNA binding MSL3,PUF60,ALX4B,RAD51D,MEIS4.1A,HLF,IRX5A,HIST1H2BF,EBF4,IRF2A
    poly(A) RNA binding ZC3H11A,DDX6,SAFB,NTPCR,KRT18,MRPS35,SUB1,NUPL2,PABPN1,DUT
    protein homodimerization activity SLC26A5,PDCD10,CLIC6,IGJ,LRRFIP1,ODZ4,DNM1L,GCA,RAB11FIP3,CTSE
    structural constituent of ribosome RPL36,RPS24,RPL35,RPL38,RPS5,RPS11,RPL13,RPL7L1,RPL21,RPL15

    Interacting Protein

    RPL7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPL7 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPL7.

    IPO5;NEDD8;ESR1;ESR2;ACTB;RAN;NFKB2;RELA;MAP3K1;NFKBIB;USP38;MAP3K14;TBK1;NR4A1

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