RPH3AL
-
Official Full Name
rabphilin 3A-like (without C2 domains) -
Overview
The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
RPH3AL;rabphilin 3A-like (without C2 domains);rab effector Noc2;Noc2;no C2 domains protein
Recombinant Proteins
- Mouse
- Rat
- Human
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- His&SUMO
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RPH3AL-14401M | Recombinant Mouse RPH3AL Protein | Mammalian Cells | Mouse | His |
|
|
| RPH3AL-5106R | Recombinant Rat RPH3AL Protein | Mammalian Cells | Rat | His |
|
|
| RPH3AL-2232HCL | Recombinant Human RPH3AL 293 Cell Lysate | HEK293 | Human | Non |
|
|
| RPH3AL-1157H | Recombinant Human RPH3AL Protein (1-315 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 1-315 aa |
|
| RPH3AL-4765R | Recombinant Rat RPH3AL Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| RPH3AL-4765R-B | Recombinant Rat RPH3AL Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
||
| RPH3AL-7718M | Recombinant Mouse RPH3AL Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| RPH3AL-7718M-B | Recombinant Mouse RPH3AL Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
RPH3AL involved in several pathways and played different roles in them. We selected most pathways RPH3AL participated on our site, such as Deregulation of Rab and Rab Effector Genes in Bladder Cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPH3AL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Deregulation of Rab and Rab Effector Genes in Bladder Cancer | SYTL3,SYTL1,RAB27A,MLPH,SYTL2,EXPH5,SYTL4,GCC2,MYRIP,UNC13D |
Protein Function
RPH3AL has several biochemical functions, for example, LIM domain binding,Rab GTPase binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPH3AL itself. We selected most functions RPH3AL had, and list some proteins which have the same functions with RPH3AL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rab GTPase binding | MYRIP,KIF16B,RABGAP1,ALS2,MICALL2,FER,RAB11FIP3,EVI5L,TBC1D30,ZFP652 |
| cytoskeletal protein binding | ANXA2B,ABI1,ALDOC,ANXA2,LIN7C,EPB4.1L4A,FRMD3,PACSIN2,FABP3,PTPN4A |
| LIM domain binding | TLN1,ACTN2,LDB1,CSRP2BP,RIPK2,LDB1A,LDB2,LDB1B,LDB2A,LDB2B |
| clathrin binding | SYT13,LRRK2,SYT12,SYT17,TOM1,SYT11,PICALM,SYT3,SYT15,SYT9B |
| calcium ion binding | ITGB1BP2,TLL2,BMP1,CCDC167,CRTAC1,EFEMP2A,PCDH1G22,F10,PCDHA8,CDH11 |
| protein binding | TPM1,NAP1L4,KIF20A,TRA2B,SEPT2,RTDR1,SCN5A,BCL2L2,CCDC141,IGF2BP1 |
| calcium-dependent phospholipid binding | SYT17,SYT11,ANXA5A,ANXA2A,SYT9B,PCLO,ANXA7,ANXA5B,SYT1B,SYT12 |
| syntaxin binding | SYT5B,STX8,VPS52,SYT12,ABCA1,ABL1,SYT15,TXLNBB,TXLNA,TMED10 |
Interacting Protein
RPH3AL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPH3AL here. Most of them are supplied by our site. Hope this information will be useful for your research of RPH3AL.
MID2;TCEA3;mutY
Resources
Related Services
Related Products
References
- Chen, JS; Kuo, YB; et al. Detection of autoantibodies against Rabphilin-3A-like protein as a potential biomarker in patient's sera of colorectal cancer. CLINICA CHIMICA ACTA 412:1417-1422(2011).
