RORB
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Official Full Name
RAR-related orphan receptor B -
Overview
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation. -
Synonyms
RORB;RAR-related orphan receptor B;nuclear receptor ROR-beta;NR1F2;ROR BETA;RZRB;bA133M9.1;Nuclear receptor RZR beta;Nuclear receptor RZR-beta;Nuclear receptor subfamily 1 group F member 2;OTTHUMP00000021486;RAR related orphan receptor B;RAR related orphan receptor beta;Retinoic acid binding receptor beta;Retinoid-related orphan receptor-beta;RORB_HUMAN;RZR BETA;RAR-related orphan receptor beta;retinoic acid-binding receptor beta;retinoid-related orphan receptor beta;nuclear receptor subfamily 1 group F me;ROR-BETA;RZR-BETA
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- Mamanlian cells
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Myc&DDK
- Non
- Flag
- His&Fc&Avi
Involved Pathway
RORB involved in several pathways and played different roles in them. We selected most pathways RORB participated on our site, such as Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with RORB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Circadian rhythm | PRKAB2,NR1D1,CRY1,NPAS2,CLOCK,SKP1,RORA,PRKAB1,PER2,FBXW11 |
Protein Function
RORB has several biochemical functions, for example, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RORB itself. We selected most functions RORB had, and list some proteins which have the same functions with RORB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | NR1H3,HNF4G,NR5A1A,NR2F6A,NR4A1,NR1H2,PPARAA,NR5A2,RORCB,PPARA |
| sequence-specific DNA binding | POU1F1,FOXI1,LHX1A,IRX4,ZNF394,RARGB,CXXC5,SOX2,NANOG,DMBX1A |
| protein binding | KIFC3,ZMYND11,PRKCD,NUP205,RPL22,EHD3,DGCR8,DOK6,SNX27,PIK3C2B |
| zinc ion binding | RNF122,TRIM68,PXN,LDB3,NSMCE2,ING2,RXRAA,MARCH3,EEA1,CAHZ |
| steroid hormone receptor activity | NR1I2,NR4A1,THRAA,RORCB,RXRA,RORA,PGRMC2,ESR2,PAQR7,NR1D4A |
| transcription factor activity, sequence-specific DNA binding | NKX6-1,ZNF394,DLX6,KLF6,E2F4,MAFBB,CEBPA,TADA2A,MEF2D,ZFP191 |
Interacting Protein
RORB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RORB here. Most of them are supplied by our site. Hope this information will be useful for your research of RORB.
Clock;BHLHE40;RORC;CSNK2B
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