RNF6
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Official Full Name
ring finger protein (C3H2C3 type) 6 -
Overview
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. -
Synonyms
RNF6;ring finger protein (C3H2C3 type) 6;E3 ubiquitin-protein ligase RNF6;DKFZp686P0776;RING H2 protein RNF 6;Ring finger protein 6;RING H2 protein;RING H2 protein RNF6;RNF 6;OTTHUMP00000018154;OTTHUMP00000018155;OTTHUMP00000018156;RING-H2 protein RNF-6
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RNF6-2348H | Recombinant Human RNF6, His-tagged | E.coli | Human | His | 1-300aa | |
| RNF6-14353M | Recombinant Mouse RNF6 Protein | Mammalian Cell | Mouse | His |
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| RNF6-1529HCL | Recombinant Human RNF6 cell lysate | Human | Non |
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| RNF6-7689M | Recombinant Mouse RNF6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| RNF6-7689M-B | Recombinant Mouse RNF6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RNF6 involved in several pathways and played different roles in them. We selected most pathways RNF6 participated on our site, such as Adaptive Immune System,Androgen receptor signaling pathway,Antigen processing: Ubiquitination &, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immune System | RNF41,BTR16,TRIM26,ACTR1A,CLEC2G,CSHL1,KIR2DS2,CASPBL,CD200,MICA |
| Androgen receptor signaling pathway | CMTM2A,CARM1,NR0B2A,ETV5A,RNF14,TGFB1I1,DSTN,SMARCE1,KAT5,HMGB2A |
| Adaptive Immune System | CD200R3,EVL,CD226,WWP1,EGFR,STIM1B,RNF220,UBR2,ARF1,ITPR2 |
| Class I MHC mediated antigen processing & | BLMH,TRAF7,UBR1,CYBA,ASB13,UBR2,NPEPPS,TRIM50,ASB4,CTSL2 |
| presentation | ASB2,SPSB1,RNF19B,RNF25,RNF144B,SEC61B,TRIM63,FBXO17,SEC24A,RNF138 |
| Antigen processing: Ubiquitination & | BLMH,UBE2E3,NPEPPS,RNF220,UBE2V2,RNF182,ASB17,ASB4,RNF123,HECTD3 |
| Proteasome degradation | TPP2,RNF144B,RNF34,UBE2V1,UCHL3,UBE2F,ASB3,TRIM39,PJA1,NPEPPS |
Protein Function
RNF6 has several biochemical functions, for example, DNA binding,androgen receptor binding,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF6 itself. We selected most functions RNF6 had, and list some proteins which have the same functions with RNF6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | HYAL3,SDCBP,DNAJC19,NFATC4,FERD3L,TCEB3,NUDCD3,FES,EZR,COLQ |
| ubiquitin protein ligase activity | BFAR,RABGEF1,RNF4,ZSWIM2,RNF7,FBXL22,PDZRN3B,ZNRF1,HERC4,SMURF1 |
| androgen receptor binding | RB1,NSD1,NRIP1,KAT5,BRCA1,NCOA3,FOXH1,CTNNB1,DDX5,CALR |
| DNA binding | ZNF311,HIST1H3G,TFDP1B,TFPT,ETS2,LIN54,CBFB,LIN28B,CDX1A,ERCC2 |
| ligase activity | RNF133,PARK2,MUL1,WWP2,UBR2,RFWD2,SYVN1,SIAH1,TRIML2,BARD1 |
| ubiquitin-protein transferase activity | TRIM27,TTC3,AMFR,FBXL14B,RNF213,TRIM28,RNF144AA,DTX3L,RNF5,CDC23 |
| zinc ion binding | PCGF5A,DIDO1,LHX1,MSRB3,RNF220A,MARCH1,UNKL,PCGF3,TRIM37,LHX6 |
Interacting Protein
RNF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF6.
AR;UBE2H;bmf_human_gene;rel1_human_gene;klk3_human_gene;RNF14
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References
- Stoll, H; et al. Filling the Gap between Pseudopotential and All-Electron Schemes: Frozen-Core Calculations with Efficient Use of Density-Fitting. JOURNAL OF CHEMICAL THEORY AND COMPUTATION 10:3857-3862(2014).
- Linn, DE; Yang, X; et al. Differential Regulation of Androgen Receptor by PIM-1 Kinases via Phosphorylation-dependent Recruitment of Distinct Ubiquitin E3 Ligases. JOURNAL OF BIOLOGICAL CHEMISTRY 287:22959-22968(2012).
