Rnf5
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Official Full Name
ring finger protein 5, E3 ubiquitin protein ligase -
Overview
The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. -
Synonyms
RNF5;RMA1;RING5;ring finger protein 5, E3 ubiquitin protein ligase;E3 ubiquitin-protein ligase RNF5;protein G16;ram1 homolog
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Mus musculus
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- In vitro E. coli expression system
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
Rnf5 involved in several pathways and played different roles in them. We selected most pathways Rnf5 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with Rnf5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | CCDC102A,PDIA4,TXNDC5,HSPA1B,UBE2G1B,LMAN1,CAPN1B,RAD23AA,BCL2A,WFS1 |
Protein Function
Rnf5 has several biochemical functions, for example, ligase activity,protein binding,ubiquitin protein ligase activity involved in ERAD pathway. Some of the functions are cooperated with other proteins, some of the functions could acted by Rnf5 itself. We selected most functions Rnf5 had, and list some proteins which have the same functions with Rnf5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | PIAS4,TNFAIP3,TRIM2,HECTD3,COP1,UBE3A,NSMCE1,MDM2,UBE2CBP,UHRF2 |
| ubiquitin protein ligase activity involved in ERAD pathway | TRIM25,STUB1,PARK2,TMEM129,SYVN1,AMFR,RNF185 |
| ubiquitin-protein transferase activity | PAX6,RNF43,FBXL21,RNF4,FBXL5,MARCH1,RNF115,UBE2D2,RNF187,RNF182 |
| zinc ion binding | TRIM35-28,ADAM15,RNF41,PCGF1,HDAC4,SIRT6,DBF4,ZEB1,USP16,DTX4 |
| protein binding | MAP4,MMRN2,CSPG5,TMEM242,SMAD1,TMEM74,PELI1,NOLC1,NRP1B,INVS |
Interacting Protein
Rnf5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Rnf5 here. Most of them are supplied by our site. Hope this information will be useful for your research of Rnf5.
UBE2D3;UBE2E3;UBE2D1;UBE2E2
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References
- Bernasconi, R; Galli, C; et al. Autoadaptive ER-Associated Degradation Defines a Preemptive Unfolded Protein Response Pathway. MOLECULAR CELL 52:783-793(2013).
- Qin, Y; Zhou, MT; et al. RNF26 Temporally Regulates Virus-Triggered Type I Interferon Induction by Two Distinct Mechanisms. PLOS PATHOGENS 10:-(2014).
