RNF40
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Official Full Name
ring finger protein 40, E3 ubiquitin protein ligase -
Overview
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] -
Synonyms
RNF40;ring finger protein 40, E3 ubiquitin protein ligase;BRE1B;RBP95;STARING;E3 ubiquitin-protein ligase BRE1B;BRE1-B;Rb-associated protein;BRE1 E3 ubiquitin ligase homolog B;95 kDa retinoblastoma-associated protein;95 kDa retinoblastoma protein binding protein
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
Involved Pathway
RNF40 involved in several pathways and played different roles in them. We selected most pathways RNF40 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF40 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
RNF40 has several biochemical functions, for example, ligase activity,mRNA 3-UTR binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF40 itself. We selected most functions RNF40 had, and list some proteins which have the same functions with RNF40. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ubiquitin-protein transferase activity | KLHL28,TCEB3B,KBTBD5,UBE2S,KLHL23,KEAP1B,KLHL24,KEAP1A,TCEB1A,KLHL22 |
| protein complex binding | CDKN1B,ATP6V1B1,MLKL,MTAP1B,ITPR1,SH2B3,NRAS,KRAS,LRP1,Apba1 |
| ubiquitin conjugating enzyme binding | DCUN1D2,PARK2,PPARA,ZMYM2,ANKIB1,DCUN1D2B,RNF217,ARIH1L,DCUN1D4,RNF144AA |
| ligase activity | SMURF1,MDM2,RNF144B,MARCH2,PIAS4,DTX2,RNF146,LTN1,RNF170,RNF152 |
| syntaxin-1 binding | STXBP3,NSF,SYT1,SNAP25A,STXBP2,GOLSYN,CCDC167,LRRK2,VAMP3,STXBP3A |
| protein homodimerization activity | KCNK9,TDG,ERBB4,XPNPEP1,GNB2L1,BAXA,PCYT1A,CADM3,IL6ST,STK10 |
| ubiquitin protein ligase binding | CBS,DAXX,NDUFS2,TRIB1,ARRB1,PTPN22,UBXN6,CKB,TOLLIP,BAG4 |
| protein binding | PSMD7,SH2D1B,FBF1,SHISA3,CD2,SPG21,SMIM3,C12orf5,PRKACB,CADPS |
| zinc ion binding | ERAP2,RNF125,TRPS1,MSL2,LONRF1L,MMP12,ZYX,APOBEC2B,BRD1B,RNF144AA |
Interacting Protein
RNF40 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF40 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF40.
RNF20;UBE2I;SFR1;CCDC146;AMOTL2
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References
- Bhatnagar, S; Gazin, C; et al. TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. NATURE 516:116-U313(2014).
- Sakai, T; Mochizuki, S; et al. The WAVY GROWTH 3 E3 ligase family controls the gravitropic response in Arabidopsis roots. PLANT JOURNAL 70:303-314(2012).
