RIT2
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Official Full Name
Ras-like without CAAX 2 -
Overview
RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 (PubMed 10545207)). -
Synonyms
RIT2;Ras-like without CAAX 2;Ric (Drosophila) like, expressed in neurons , RIN;GTP-binding protein Rit2;RIBA;GTP binding protein Rit2;GTP binding protein Roc2;Ras like protein expressed in neurons;Ras like without CAAX 2;Ras like without CAAX protein 2;Ras-like protein expressed in neurons;Ras-like without CAAX protein 2;Ric (Drosophila) like;Ric like;RIN;RIT2_HUMAN;ROC2;OTTHUMP00000163445;GTP-binding protein Roc2;Ric-like, expressed in neurons
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
RIT2 involved in several pathways and played different roles in them. We selected most pathways RIT2 participated on our site, such as NGF signalling via TRKA from the plasma membrane,Neurotrophic factor-mediated Trk receptor signaling,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with RIT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signalling to ERKs | RIT1,KIDINS220B |
| Signalling by NGF | PCSK6,KIDINS220B,LINGO1,PRDM4,AATF,DNAL4B,DNAL4,RTN4A,DNAL4A,PCSK5 |
| NGF signalling via TRKA from the plasma membrane | KIDINS220B,DNAL4,RIT1,ADCYAP1,DNAL4A,NTF7,DNAL4B |
| Signal Transduction | SKILB,WIPF2,FAM13B1,ADH8A,SOX6,TRIM33,OPN1SW1,HEBP1,CHRDL1,MYO9B |
| Trk receptor signaling mediated by the MAPK pathway | RIT1,RUSC1 |
| Signalling to p38 via RIT and RIN | RIT1 |
| Neurotrophic factor-mediated Trk receptor signaling | GIPC1,RGS19,FAIM,MCF2L,DYNLT1,RIT1 |
Protein Function
RIT2 has several biochemical functions, for example, GTP binding,GTPase activity,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RIT2 itself. We selected most functions RIT2 had, and list some proteins which have the same functions with RIT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activity | ATL1,TUBB4A,EEF1A1,RAB18A,RAB5B,GUF1,MFN2,RAB3B,GNA13A,GNAZ |
| calmodulin binding | CAMKK1,CNGA2,ADD1,MAPKAPK5,USP6,INVS,MYO1F,PCP4,PHKB,MARCKSL1 |
| GTP binding | RAB40C,RND1L,ARL4D,CDC42L2,NUDT16,EEF1A1L2,PCK2,GIMAP8,SEPT5A,DIRAS3 |
Interacting Protein
RIT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RIT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RIT2.
SRPK2;GRB2
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References
- Liscovitch, N; French, L; et al. Differential Co-Expression between alpha-Synuclein and IFN-gamma Signaling Genes across Development and in Parkinson's Disease. PLOS ONE 9:-(2014).
- Finno, CJ; Aleman, M; et al. Risk of false positive genetic associations in complex traits with underlying population structure: A case study. VETERINARY JOURNAL 202:543-549(2014).
