RIPK4
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Official Full Name
receptor-interacting serine-threonine kinase 4 -
Overview
The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. -
Synonyms
RIPK4;receptor-interacting serine-threonine kinase 4;ANKRD3, ankyrin repeat domain 3;receptor-interacting serine/threonine-protein kinase 4;ANKK2;DIK;PKC delta interacting protein kinase;PKK;protein kinase C associated kinase;RIP4;protein kinas
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RIPK4-12307Z | Recombinant Zebrafish RIPK4 | Mammalian Cell | Zebrafish | His |
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| RIPK4-14246M | Recombinant Mouse RIPK4 Protein | Mammalian Cell | Mouse | His |
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| RIPK4-5925H | Recombinant Human RIPK4 Protein (Phe22-Ile286), N-GST tagged | E.coli | Human | GST | Phe22-Ile286 |
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| RIPK4-7617M | Recombinant Mouse RIPK4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| RIPK4-7617M-B | Recombinant Mouse RIPK4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RIPK4 involved in several pathways and played different roles in them. We selected most pathways RIPK4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RIPK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
RIPK4 has several biochemical functions, for example, ATP binding,kinase activity,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RIPK4 itself. We selected most functions RIPK4 had, and list some proteins which have the same functions with RIPK4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinase activity | CCL3,STK35L,PHKG1A,LMTK2,PAK2B,CDKN1BB,PRKCBP1L,PLK1,ROCK2B,ADKA |
| nucleotide binding | ABCA13,RHOU,BAT1,MAPK12B,RHOGA,A1CF,DNM1A,GSK3AA,ABCG2D,GM7168 |
| transferase activity | FTSJD2,GSTT4,CDK5R1B,ST6GAL2A,ADKB,RAF1B,DCKL1B,PRIM2,LIMK1A,Fert2 |
| protein binding | TRAPPC2L,COG1,TMEM120B,DYNLT3,BLOC1S3,SPATA22,BFAR,GNL3L,RP9,CLTC |
| protein kinase activity | PRKCD,MKNK2A,CHUK,EGFRA,WNK2,DCLK1A,RPS6KB1,CDK11A,EEF2K,CSNK1D |
| ATP binding | MAP2K7,MVK,NETO2,SARS2,EARS2,ABCD4,BMX,EK1,MAT2AA,PFAS |
| protein serine/threonine kinase activity | STK16,CSNK1A1L,MASTL,ULK4,SMOK3A,MAP3K2,BMPR1A,DCLK3,STK32A,DSTYK |
Interacting Protein
RIPK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RIPK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RIPK4.
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References
- Leslie, EJ; O'Sullivan, J; et al. Expanding the Genetic and Phenotypic Spectrum of Popliteal Pterygium Disorders. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 167A:545-552(2015).
- Heim, D; Cornils, K; et al. Retroviral insertional mutagenesis in telomerase-immortalized hepatocytes identifies RIPK4 as novel tumor suppressor in human hepatocarcinogenesis. ONCOGENE 34:385-393(2015).
