Ric8
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Official Full Name
resistance to inhibitors of cholinesterase 8 homolog (C. elegans) -
Synonyms
RIC-8;Ric8a;AI114950
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RIC8-14218M | Recombinant Mouse RIC8 Protein | Mammalian Cell | Mouse | His |
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| RIC8-7600M | Recombinant Mouse RIC8 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
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| RIC8-7600M-B | Recombinant Mouse RIC8 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
Ric8 involved in several pathways and played different roles in them. We selected most pathways Ric8 participated on our site, such as cyclic AMP biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ric8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cyclic AMP biosynthesis | RALGAPA1,DOCK8,GARNL3,RAP1GAP2,PDC,ARHGAP33 |
Protein Function
Ric8 has several biochemical functions, for example, G-protein alpha-subunit binding,GTPase activator activity,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ric8 itself. We selected most functions Ric8 had, and list some proteins which have the same functions with Ric8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein alpha-subunit binding | NUCB1,AGTR1A,F2RL1,ADRB2,PPP5C,DRD1A,RIC8B,OPRM1,LPAR1,RGS19 |
| guanyl-nucleotide exchange factor activity | ARHGEF18,FGD1,ANKRD27,FGD3,GCGR,RINL,VAV1,ARFGEF2,RAPGEF3,BCAR3 |
| protein binding | DSCAM,FAM192A,CHEK1,HOMER3,TFAP2A,SPANXA1,CITED2,EXOSC1,ADPRH,FDX1L |
| GTPase activator activity | STXBP5L,RP2,FAM13A,CHN2,ASAP1A,TBC1D20,TBC1D21,RASA1,TBC1D14,ARHGAP10 |
Interacting Protein
Ric8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ric8 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ric8.
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References
- Gong, JJ; Grodsky, JD; et al. A Ric8/Synembryn Homolog Promotes Gpa1 and Gpa2 Activation To Respectively Regulate Cyclic AMP and Pheromone Signaling in Cryptococcus neoformans. EUKARYOTIC CELL 13:1290-1299(2014).
- de Mendoza, A; Sebe-Pedros, A; et al. The Evolution of the GPCR Signaling System in Eukaryotes: Modularity, Conservation, and the Transition to Metazoan Multicellularity. GENOME BIOLOGY AND EVOLUTION 6:606-619(2014).
