RHAG
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Official Full Name
Rh-associated glycoprotein -
Overview
The protein encoded by this gene is erythrocyte-specific and is thought to be part of a membrane channel that transports ammonium and carbon dioxide across the blood cell membrane. The encoded protein appears to interact with Rh blood group antigens and Rh30 polypeptides. Defects in this gene are a cause of regulator type Rh-null hemolytic anemia (RHN), or Rh-deficiency syndrome. -
Synonyms
RHAG;Rh-associated glycoprotein;Rhesus blood group associated glycoprotein;ammonium transporter Rh type A;CD241;RH50A;SLC42A1;Abnormal Rhesus blood group associated glycoprotein;CD241 antigen;Erythrocyte membrane glycoprotein Rh50;Erythrocyte plasma membrane 50 kDa glycoprotein;Rh associated glycoprotein;RH2;RH50;Rh50 glycoprotein;Rh50 GP;Rhesus blood group associated ammonia channel;rh type A glycoprotein;rh family type A glycoprotein;Rhesus associated polypeptide, 50-KD;Rhesus blood group-associated glycoprotein;rhesus blood group family type A glycoprotein;rhesus blood group-associated ammonia channel;Rh50GP
Recombinant Proteins
- Zebrafish
- Mouse
- Rat
- Rhesus macaque
- Chicken
- Human
- Mammalian Cells
- E.coli
- HEK293
- His
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
RHAG involved in several pathways and played different roles in them. We selected most pathways RHAG participated on our site, such as Erythrocytes take up carbon dioxide and release oxygen,Erythrocytes take up oxygen and release carbon dioxide,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with RHAG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | CYP2B6,PDK2,NUDT3,PIK3R6,CYP2Y3,GLYATL1,ARL2BP,NAMPT,MARCKSA,UPP2 |
| Transmembrane transport of small molecules | AZGP1,FKBP1B,TRPA1A,SLC29A4,SLC28A3,SLC31A1,SLC35B4,SLC30A1A,FTH1A,TTYH1 |
| O2/CO2 exchange in erythrocytes | AQP1A.2,SLC4A1B,SLC4A1A,AQP1A.1 |
| Erythrocytes take up oxygen and release carbon dioxide | SLC4A1A,SLC4A1B,AQP1A.2,AQP1A.1 |
| SLC-mediated transmembrane transport | SLC22A7B.1,SLC35A3,SLC7A3,SLC39A3,SLC7A11,SLC6A19A,SLC39A6,SLC35A3A,SLC2A13B,SLC1A7A |
| Rhesus glycoproteins mediate ammonium transport. | RHCGL1,RHCGA,RHBG,RHCG,RHCGB,RHCG2A |
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | SLC22A6,RHCGL1,SLC2A13B,SLC39A14,SLC44A5B,SLC5A9,SLC6A19B,SLC6A20B,SLC39A6,SLC13A1 |
| Erythrocytes take up carbon dioxide and release oxygen | AQP1A.2,SLC4A1A,SLC4A1B,AQP1A.1 |
Protein Function
RHAG has several biochemical functions, for example, ammonium transmembrane transporter activity,ankyrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RHAG itself. We selected most functions RHAG had, and list some proteins which have the same functions with RHAG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ammonium transmembrane transporter activity | RHCE,RHCG,RHCGL1,AQP1,RHCGB,AQP1A.2,RHD,RH50,AQP1A.1,RHBG |
| ankyrin binding | KCNQ2,CDH1,OBSCN,ATP1A1,KCNJ11,SCN5A,RHBG,RHCG,NRCAM,PLEC |
Interacting Protein
RHAG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RHAG here. Most of them are supplied by our site. Hope this information will be useful for your research of RHAG.
Resources
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References
- Hsu, K; Lee, TY; et al. Expression of the Rh/RhAG complex is reduced in Mi.III erythrocytes. VOX SANGUINIS 102:221-227(2012).
- Wood, CM; Nawata, CM; et al. Rh proteins and NH4+-activated Na+-ATPase in the Magadi tilapia (Alcolapia grahami), a 100% ureotelic teleost fish. JOURNAL OF EXPERIMENTAL BIOLOGY 216:2998-3007(2013).
