RGS17
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Official Full Name
regulator of G-protein signaling 17 -
Overview
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. -
Synonyms
RGS17;regulator of G-protein signaling 17;regulator of G protein signalling 17;RGS 17;RGSZ2;Regulator of G protein signalling Z2;RGS17_HUMAN;RGS-17;hRGS17
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RGS17-3639H | Recombinant Human RGS17, His-tagged | Human | Human | His |
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| RGS17-6404C | Recombinant Chicken RGS17 | Mammalian Cells | Chicken | His |
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| RGS17-647Z | Recombinant Zebrafish RGS17 | Mammalian Cells | Zebrafish | His |
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| RGS17-2382HCL | Recombinant Human RGS17 293 Cell Lysate | HEK293 | Human | Non |
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| RGS17-6322H | Recombinant Human RGS17 protein, His-tagged | E.coli | Human | His | 165aa(including fusion tag) |
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Involved Pathway
RGS17 involved in several pathways and played different roles in them. We selected most pathways RGS17 participated on our site, such as Calcium Regulation in the Cardiac Cell,G alpha (z) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G alpha (z) signalling events | ADRA2B,RGS20,ADRA2C,RGS19,RGS4,ADRA2A |
| GPCR downstream signaling | OBSCN,TAS2R3,ADCYAP1B,PMCH,ADCYAP1,FGD4,OXGR1A.2,APPB,CCL19A.2,NPS |
| Myometrial Relaxation and Contraction Pathways | RAMP2,CORIN,ACTA1,RGS4,RGS11,IGFBP4,ATF5,GABPA,GUCA2A,RAMP3 |
| Calcium Regulation in the Cardiac Cell | AKR1C1,CX35.4,GNB3B,CX55.5,ADRA1D,KCNB1,RGS14A,GJC1,ADRa1A,CHRM4 |
| Signal Transduction | NEDD8L,MLN,RSPO1,LPAR2A,DNAL4A,RBP2A,PPEF1,NRP2,CNR2,RNF31 |
| Signaling by GPCR | GPR37B,PENK,OPN4B,GPR132B,TAS2R3,PTHRP2,PENKA,CXCL11.8,GPR120,CRHB |
Protein Function
RGS17 has several biochemical functions, for example, GTPase activator activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS17 itself. We selected most functions RGS17 had, and list some proteins which have the same functions with RGS17. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | AGFG1B,MURC,ARHGDIA,CDC42EP1,TBC1D2B,DOCK4,ARHGAP31,DLC1,LLGL1,RGS16 |
| protein binding | RABGAP1L,PDLIM3,BAP1,MAPK3,CLEC16A,ANKHD1,TRPC7,SEC24A,HOXB9,TNS4 |
Interacting Protein
RGS17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS17 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS17.
NUFIP2;57647;GNAI3;AQP1;OTX1;HOXA1;SMCP
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References
- Ajit, SK; Ramineni, S; et al. RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling. CELLULAR SIGNALLING 19:723-730(2007).
