RGS14
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Official Full Name
regulator of G-protein signaling 14 -
Overview
This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. -
Synonyms
RGS14;regulator of G-protein signaling 14;regulator of G protein signalling 14;regulator of G-protein signalling 14
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
RGS14 involved in several pathways and played different roles in them. We selected most pathways RGS14 participated on our site, such as Calcium Regulation in the Cardiac Cell,G alpha (i) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | TAS2R3,ABI1A,BCO2L,OPN4,APLN,HEYL,ARHGAP32,PTH,RAB6A,LRP12 |
| Signaling by GPCR | UTS2,OR52J3,RGS10,FGD4A,NMB,S1PR5B,GPR31B,DCLRE1B,TAC3,PROK2 |
| GPCR downstream signaling | NMBB,TRPC6A,KALRNB,GCGA,CCR1,RGS4,PIK3R6,PNOC,ADORA1,GPBAR1 |
| Myometrial Relaxation and Contraction Pathways | MAFF,RGS16,RGS10,RAMP3,RGS6,CRHR1,RGS18,MYLK2,GPR182,RGS20 |
| Calcium Regulation in the Cardiac Cell | GJA3,CX27.5,CX30.3,GNB3B,CHRM4,RGS7,RGS11,CHRM1,RGS20,GJC2 |
| Rap1 signaling pathway | EFNA2,EFNA4,CSF1,PFN4,LOC608458 |
| G alpha (i) signalling events | SST1.1,RGS10,RGS11,GPR55A,PYYA,INSL5,FPR-RS3,ADRA2A,GPR18,HRH3 |
Protein Function
RGS14 has several biochemical functions, for example, G-protein alpha-subunit binding,GDP-dissociation inhibitor activity,GTPase activating protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS14 itself. We selected most functions RGS14 had, and list some proteins which have the same functions with RGS14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | RGS4,ARHGAP5,ARHGDIG,RP2,GRTP1,SIPA1L1,BAI3,ARHGAP1,GRTP1A,ARHGAP17 |
| microtubule binding | MAP1LC3B,KIF4,KIF3CB,MARK4,CLASP1,HDAC6,MTAP1A,KIF3A,CHP,MAP1S |
| G-protein alpha-subunit binding | RGS4,HTR2B,IGF1R,F2R,RIC8A,OPRM1,RGS19,NUCB1,DRD1,AGTR1A |
| GTPase activating protein binding | PTBP3,TUBB,CDH1,GAPVD1,GNAO1,FMNL1,GNAI3,TSC1,PLCD1,MEX3B |
| GDP-dissociation inhibitor activity | RANBP1,SH3BP4A,SH3BP4,GPSM1,ITGB1BP1,GPSM1B,GPSM2L,GDI1 |
| protein binding | ALPP,LDHAL6B,CTNNBL1,USP10,DBNL,KCNA5,DCTN1,XRCC4,ARMCX5-GPRASP2,SH2B1 |
| receptor signaling complex scaffold activity | SPAG9,SHANK1,LDLRAP1,CD3G,SPAG9A,GRIP1,NCK2,CARD10,G3BP2,DEDD2 |
| receptor signaling protein activity | NGF,SMAD1,FLRT1,PDCL,DCLK1,DOK4,PLCE1,FLRT2,ADRB1,CD3E |
Interacting Protein
RGS14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS14 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS14.
TINF2;GNAI1;GNAI1;XPO1;GNAI3;NFKB1;WAS;TRAF2;POT1
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References
- Evans, PR; Lee, SE; et al. Postnatal Developmental Expression of Regulator of G Protein Signaling 14 (RGS14) in the Mouse Brain. JOURNAL OF COMPARATIVE NEUROLOGY 522:186-203(2014).
