RFX5
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Official Full Name
regulatory factor X, 5 (influences HLA class II expression) -
Overview
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. -
Synonyms
RFX5;regulatory factor X, 5 (influences HLA class II expression);DNA-binding protein RFX5;DNA binding protein RFX 5;DNA binding protein RFX5;Influences HLA class II expression;Regulatory factor X 5;Regulatory factor X subunit 5;RFX 5;Rfx5 protein;OTTHUMP00000014465;OTTHUMP00000081737;OTTHUMP00000082795;OTTHUMP00000082796;OTTHUMP00000196318;OTTHUMP00000196321
Recombinant Proteins
- Rhesus macaque
- Human
- Mouse
- Mammalian Cell
- HEK293
- E.coli
- HEK293T
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RFX5-3863R | Recombinant Rhesus monkey RFX5 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| RFX5-2396HCL | Recombinant Human RFX5 293 Cell Lysate | HEK293 | Human | Non |
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| RFX5-001H | Recombinant Human RFX5 protein, His-tagged | E.coli | Human | His | 391-616 a.a. |
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| Rfx5-001M | Recombinant Mouse Rfx5 protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| RFX5-002H | Recombinant Full Length Human RFX5 protein, Myc/DDK-tagged | HEK293T | Human | Myc&DDK | Full L. 1-576 a.a. |
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| RFX5-332H | Recombinant Human RFX5 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| RFX5-3680R | Recombinant Rhesus Macaque RFX5 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| RFX5-3680R-B | Recombinant Rhesus Macaque RFX5 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| Rfx5-5482M | Recombinant Full Length Mouse Rfx5 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK | Full L. 1-658 a.a. |
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Involved Pathway
RFX5 involved in several pathways and played different roles in them. We selected most pathways RFX5 participated on our site, such as Antigen processing and presentation,Tuberculosis,Primary i, which may be useful for your reference. Also, other proteins which involved in the same pathway with RFX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing and presentation | CANX,CD8B1,CD4,HLA-DQA1,NFYC,KIR3DL2,TNF,HLA-DQB1,HLA-F,RFXAP |
| Primary i | AIRE,RFXAP,BTK,UNG,CD8B1,LCK,ICOS,RAG1,CD79A,IGLL1 |
| nodeficiency | IL7R,CD8B,CD3E,IKBKG,ICOS,RFXANK,CD3D,CD4, Cd79b,TNFRSF13B |
| Tuberculosis | MAPK1,PPP3R2,BCL2,TLR1,MRC2,Cd209g,ATP6V0D1,HSPD1,FCGR3,HLA-DMA |
Protein Function
RFX5 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RFX5 itself. We selected most functions RFX5 had, and list some proteins which have the same functions with RFX5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | ZFP629,NFIA,ZNF83,TRPS1,ZNF92,PAX6,TCF3B,ETS2,NFYA,HOXC4A |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | PRDM5,CARF,GZF1,MYF6,MEIS1,ZIC3,HAND1,HINFP,NEUROD1,ATF7 |
| protein binding | VCPKMT,PPID,PCDH17,NUP62L,AOC3,MIA3,VTA1,HSPB8,CDK15,RBM26 |
| DNA binding | IRX5B,AHRRA,PRRX1A,ZNF711,TCEANC2,PPARG,FOXD5,MCM6L,CRAMP1L,ZBTB25 |
Interacting Protein
RFX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RFX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of RFX5.
HDAC2;lysA;collagen sequence;RFXAP;SIN3B;CDC73;GIGYF2;CDC5L
Resources
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References
- Surmann, EM; Voigt, AY; et al. Association of high CD4-positive T cell infiltration with mutations in HLA class II-regulatory genes in microsatellite-unstable colorectal cancer. CANCER IMMUNOLOGY IMMUNOTHERAPY 64:357-366(2015).
- Michel, S; Linnebacher, M; et al. Lack of HLA class II antigen expression in microsatellite unstable colorectal carcinomas is caused by mutations in HLA class II regulatory genes. INTERNATIONAL JOURNAL OF CANCER 127:889-898(2010).
