RDH10
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Official Full Name
retinol dehydrogenase 10 (all-trans) -
Overview
This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. [provided by RefSeq, Dec 2011] -
Synonyms
RDH10;retinol dehydrogenase 10 (all-trans);SDR16C4;retinol dehydrogenase 10;short chain dehydrogenase/reductase family 16C, member 4
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Rat
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
RDH10 involved in several pathways and played different roles in them. We selected most pathways RDH10 participated on our site, such as Metabolic pathways,RA biosynthesis pathway,Retinol metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with RDH10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by Retinoic Acid | PDK2B,PDK3,ALDH8A1,CRABP2B,RARG,CRABP2A,CRABP1,RDH14,DHRS4,RDH7 |
| Metabolic pathways | PLCD1A,GATM,BCAT1,HSD17B12A,ALDH2,HPDB,CPOX,ALG10B,GM5506,G6PC |
| Signal Transduction | CCRL2,RCA2.1,CXCR7B,TAC1,TAGAP,SOX6,OPN5,ARHGAP17,OPHN1,TAC3 |
| RA biosynthesis pathway | CRABP1,DHRS9,ADH8B,DHRS3,DHRS4,RDH14B,ALDH8A1,CRABP1A,SDR16C5,CRABP1B |
| Retinol metabolism | CYP3A65,RDH8A,CYP3A41B,AOX3L1,UGT2A3,BCMO1,BCO1L,UGT1A6,UGT2B15,UGT1A7C |
| Visual phototransduction | LRP12,STRA6,APOM,APOA4B.2,BCO2,RPE65B,RPE65A,DHRS3,METAP2B,MYO7A |
| The canonical retinoid cycle in rods (twilight vision) | IRBP,RDH12,RPE65B,RLBP1A,SDR9C7,ABCA4A,DHRS9,RLBP1B,RPE65A,STRA6 |
| Vitamin A and carotenoid metabolism | RARG,DHRS3,BCO2,RDH12,RBP7,CRABP2,CRABP1 |
Protein Function
RDH10 has several biochemical functions, for example, NADP-retinol dehydrogenase activity,retinol dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RDH10 itself. We selected most functions RDH10 had, and list some proteins which have the same functions with RDH10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADP-retinol dehydrogenase activity | RDH8,RDH10A,DHRS3,RDH10B,RDH11 |
| retinol dehydrogenase activity | DHRS3,RDH12,RDH5,HSD17B6,AKR1C3,RDH7,ADH1,SDR9C7,SDR16C5,BMP2 |
Interacting Protein
RDH10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RDH10 here. Most of them are supplied by our site. Hope this information will be useful for your research of RDH10.
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