RCOR1
-
Official Full Name
REST corepressor 1 -
Overview
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011] -
Synonyms
RCOR1;REST corepressor 1;RCOR;COREST
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- His
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RCOR1-001H |
Recombinant Human REST corepressor 1 Protein, His tagged
|
E.coli | Human | His | 394-482 aa | |
| RCOR1-14038M | Recombinant Mouse RCOR1 Protein | Mammalian Cells | Mouse | His |
|
|
| RCOR1-1852H | Recombinant Human REST Corepressor 1, His-tagged | E.coli | Human | His | 305-end a.a. |
|
| RCOR1-4984Z | Recombinant Zebrafish RCOR1 | Mammalian Cells | Zebrafish | His |
|
|
| RCOR1-71H | Recombinant Human RCOR1 protein, His-tagged | E.coli | Human | His | 294-485 |
|
| RCOR1-73H | Recombinant Human RCOR1 protein, GST-tagged | Wheat Germ | Human | GST | 1-482 a.a. |
|
| RCOR1-301383H | Recombinant Human RCOR1 protein, GST-tagged | E.coli | Human | GST | Met245-Pro310 |
|
| RCOR1-7502M | Recombinant Mouse RCOR1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| RCOR1-7502M-B | Recombinant Mouse RCOR1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
RCOR1 involved in several pathways and played different roles in them. We selected most pathways RCOR1 participated on our site, such as Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with RCOR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Huntingtons disease | NDUFS5,UQCRH,COX6A1,Casp3,COX7A2,BDNF,DNAI2,EP300,NDUFA4,NDUFB9 |
Protein Function
RCOR1 has several biochemical functions, for example, DNA binding,enzyme binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RCOR1 itself. We selected most functions RCOR1 had, and list some proteins which have the same functions with RCOR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription regulatory region DNA binding | TP73,DHX36,TP63,KLF1,ZNF649,ZNF335,PAX2,ZFP821,CREB3L2,MTERF3 |
| DNA binding | DMRT2,CREMB,ZFP423,HOXD12,ZNF544,ZNF786,RFX3,PBRM1,ZMYM4,MSH2 |
| enzyme binding | SCNM1-PS,AKT1,SIRT3,USF1,TMBIM6,TSPAN14,CAT,MAT2B,MAPT,TSPYL1 |
| protein binding | MED1,WWC1,UBE2D2,COMMD3,HSP90AA1.1,RBM3,MKRN2,GPKOW,FLII,WBP4 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | ZGPAT,CC2D1B,ZKSCAN3,TCF21,NR2C1,HAND1,EN1,TCF3,SREBF2,MYPOP |
Interacting Protein
RCOR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RCOR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RCOR1.
Nr4a2;Gfi1b;inos_mouse_gene;tnfa_mouse_gene;Hdac1;Hdac2;Nanog
Resources
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References
- Pilotto, S; Speranzini, V; et al. Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:2752-2757(2015).
- Meier, K; Brehm, A; et al. Chromatin regulation: How complex does it get?. EPIGENETICS 9:1485-1495(2014).
