RCAN1

  • Official Full Name

    regulator of calcineurin 1

  • Overview

    The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.

  • Synonyms

    RCAN1;regulator of calcineurin 1;Down syndrome critical region gene 1 , DSCR1;calcipressin-1;Adapt 78;Adapt78;Calcipressin 1;Calcium and oxidant inducible mRNA;CSP 1;CSP1;Down syndrome candidate region 1;Down syndrome critical region gene 1;Down syndrome critical region protein 1;DSC 1;DSC1;DSCR 1;DSCR1;MCIP 1;MCIP1;Modulatory calcineurin interacting protein 1;Myocyte enriched calcineurin interacting protein 1;Myocyte-enriched calcineurin-interacting protein 1;Near DSCR proline rich protein;RCAN1_HUMAN;RCN 1;RCN1;OTTHUMP00000108619;OTTHUMP00000108620;OTTHUMP00000108621;OTTHUMP00000108622;OTTHUMP00000214669;OTTHUMP00000214670;near DSCR proline-rich protein;calcium and oxidant-inducible mRNA;Down syndrome critical regi

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • HIS
  • Non
  • GST
  • His
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
RCAN1-088H Recombinant Human RCAN1 Protein, HIS-tagged E.coli Human HIS
RCAN1-27792TH Recombinant Human RCAN1 E.coli Human Non 1-117 a.a.
RCAN1-298H Recombinant Human Regulator of Calcineurin 1 E.coli Human Non 1-117 a.a.
RCAN1-4029H Recombinant Human RCAN1 Protein, GST-tagged Wheat Germ Human GST
RCAN1-4972R Recombinant Rat RCAN1 Protein Mammalian Cells Rat His
RCAN1-5347C Recombinant Chicken RCAN1 Mammalian Cells Chicken His
RCAN1-510HCL Recombinant Human RCAN1 cell lysate Human Non
RCAN1-3958H Recombinant Human RCAN1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK
RCAN1-4631R Recombinant Rat RCAN1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
RCAN1-4631R-B Recombinant Rat RCAN1 Protein Pre-coupled Magnetic Beads HEK293 Rat
RCAN1-4708HF Recombinant Full Length Human RCAN1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 197 amino acids
Rcan1-5433M Recombinant Mouse Rcan1 Protein, Myc/DDK-tagged HEK293 Mouse Myc&DDK
RCAN1-5723H Recombinant Human RCAN1 Protein (Met56-Ser252), N-His tagged E.coli Human His Met56-Ser252

    Involved Pathway

    RCAN1 involved in several pathways and played different roles in them. We selected most pathways RCAN1 participated on our site, such as Calcium signaling in the CD4+ TCR pathway,MicroRNAs in cardiomyocyte hypertrophy,Notch-mediated HES/HEY network, which may be useful for your reference. Also, other proteins which involved in the same pathway with RCAN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Notch-mediated HES/HEY network ASCL1,TLE1,MYOD1,GATA1,GATA6,YY1,MYB,HEY1,BGLAP,HES6
    Calcium signaling in the CD4+ TCR pathway POU2F1,FKBP1A,CSF2,CHP,RCAN2,JUNB,BATF3,AKAP5
    Oxytocin signaling pathway GNAI2,RGS2,MAPK3,CACNG1,CACNA2D1,MAP2K1,PPP3CA,PPP3R1,CACNG6,MYL6
    Role of Calcineurin-dependent NFAT signaling in lymphocytes RCAN2,CHP,FKBP8
    Thyroid hormone signaling pathway SIN3A,ITGAV,PRKACA,PIK3R5,ACTB,TP53,ATP1A1,GSK3B,PIK3R1,MED13
    MicroRNAs in cardiomyocyte hypertrophy CTF1,MYEF2

    Protein Function

    RCAN1 has several biochemical functions, for example, DNA binding,calcium-dependent protein serine/threonine phosphatase regulator activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RCAN1 itself. We selected most functions RCAN1 had, and list some proteins which have the same functions with RCAN1. You can find most of the proteins on our site.

    Function Related Protein
    calcium-dependent protein serine/threonine phosphatase regulator activity RCAN1A,RCAN2,RCAN3
    transcription factor activity, sequence-specific DNA binding GLI2,DLX3,CREB3,FOXG1D,E2F3,SLC26A3,YEATS4,ZIC2,FOXK2,FOXE1
    DNA binding PARP2,KLF8,POLR1E,SPI1B,FBXO21,ZNF230,LBX1,ZNF41,DHX36,AIFM2
    identical protein binding RYR2,CLDN7,NUP153,MCM10,USP2,DVL2,NPR2,CRYBB2,RIPK1,SAFB2
    protein binding PIGK,GFOD1,C22orf39,YWHAE,PLEK,SSSCA1,COMP,CRLF1,STK38L,RNF175

    Interacting Protein

    RCAN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RCAN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RCAN1.

    PRKACB

    Resources

    References

    • Kang, S; Ren, D; et al. Cell Line Profiling to Improve Monoclonal Antibody Production. BIOTECHNOLOGY AND BIOENGINEERING 111:748-760(2014).
    • Ermak, G; Pritchard, MA; et al. Do RCAN1 proteins link chronic stress with neurodegeneration?. FASEB JOURNAL 25:3306-3311(2011).

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