RBBP8
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Official Full Name
retinoblastoma binding protein 8 -
Overview
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008] -
Synonyms
RBBP8;retinoblastoma binding protein 8;RIM;COM1;CTIP;JWDS;SAE2;SCKL2;DNA endonuclease RBBP8;RBBP-8;CTBP-interacting protein;sporulation in the absence of SPO11 protein 2 homolog
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&Fc&Avi
Involved Pathway
RBBP8 involved in several pathways and played different roles in them. We selected most pathways RBBP8 participated on our site, such as BARD1 signaling events,Cell Cycle,DNA Double-Strand Break Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBBP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) | PPP4R2B,UIMC1,PPP4R2A,KIAA0146,RAD1,EME1,RNF4,RAD9,BABAM1,RNF168 |
| HDR through Homologous Recombination (HRR) | FUZ,RHNO1,TOPBP1,EME2,KIAA0146,RAD9B,WRN,RAD9,HUS1,RAD51AP1 |
| E2F transcription factor network | CES1,CBX5,RYBP,TRIM28,UXT,SMARCA2,CES5A,CES3,YY1,CEBPA |
| Cell cycle | CHEK1,CDKN1B,POT1,CSNK1D,RANGAP1B,RAD9B,ENSA,CSNK2A1,MND1,VRK2 |
| BARD1 signaling events | RAD50,CDK2,CSTF1,BARD1,NPM1 |
| DNA Double-Strand Break Repair | EME2,UBE2V2,EYA4,CHEK1,PPP4CB,SMARCA5,CHEK2,EYA2,PARP1,BARD1 |
| DNA Repair | CHEK1,RAD9A,ASCC3,ZFP830,BRCC3,DCLRE1A,RNF111,PPP4R2A,INO80C,FUZ |
Protein Function
RBBP8 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding,RNA polymerase II transcription corepressor activity,damaged DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBBP8 itself. We selected most functions RBBP8 had, and list some proteins which have the same functions with RBBP8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GAB2,HLA-DRB3,ADRA2C,FNTB,SLPI,RFC2,IWS1,TXNL4A,ARPC3,NOL4 |
| RNA polymerase II transcription corepressor activity | UXT,CITED2,BEND6,SIN3AA,TBX15,URI1,HEYL,SIN3A,RERE,OLIG3 |
| RNA polymerase II repressing transcription factor binding | HDAC1,BBS5,TBX5A,SP1,MKKS,BBS1,DMAP1,TCERG1,MIXL1,CHD4 |
| single-stranded DNA endodeoxyribonuclease activity | MRE11A,ERCC4,DCLRE1C,SETMAR |
| damaged DNA binding | XPA,RAD23AB,DCLRE1C,RPS3,DCLRE1A,NEIL2,XPC,RPA2,RAD23AA,TDG |
Interacting Protein
RBBP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBBP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBBP8.
BRCA1;CTBP1;EXO1;RBL2;AATF
Resources
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References
- Fresu, M; Bianchi, M; et al. Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase. BIOCHEMICAL JOURNAL 358:407-414(2001).
- Kim, HS; Hausman, GJ; et al. The expression of cyclin D1 during adipogenesis in pig primary stromal-vascular cultures. OBESITY RESEARCH 9:572-578(2001).
