RASGRP3

  • Official Full Name

    RAS guanyl releasing protein 3 (calcium and DAG-regulated)

  • Overview

    Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated;switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs),;such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and;are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 (PubMed 10934204)).

  • Synonyms

    RASGRP3;RAS guanyl releasing protein 3 (calcium and DAG-regulated);ras guanyl-releasing protein 3;GRP3;KIAA0846;guanine nucleotide exchange factor for Rap1;calcium and DAG-regulated guanine nucleotide exchange factor III

Recombinant Proteins

  • Human
  • Chicken
  • Rhesus macaque
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
RASGRP3-2190H Recombinant Human RASGRP3, GST-tagged E.coli Human GST C-term-349aa
RASGRP3-1543C Recombinant Chicken RASGRP3 Mammalian Cells Chicken His
RASGRP3-3794R Recombinant Rhesus monkey RASGRP3 Protein, His-tagged Mammalian Cells Rhesus macaque His
RASGRP3-405H Recombinant Human RASGRP3 Protein, GST/His-tagged E.coli Human GST&His
RASGRP3-6184Z Recombinant Zebrafish RASGRP3 Mammalian Cells Zebrafish His
RASGRP3-2504HCL Recombinant Human RASGRP3 293 Cell Lysate HEK293 Human Non
RASGRP3-3611R Recombinant Rhesus Macaque RASGRP3 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
RASGRP3-3611R-B Recombinant Rhesus Macaque RASGRP3 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Rasgrp3-5391M Recombinant Mouse Rasgrp3 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc

    Involved Pathway

    RASGRP3 involved in several pathways and played different roles in them. We selected most pathways RASGRP3 participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASGRP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rap signaling pathway MAPK1,AKT2,MAPK12,MAP2K2,FGF13,MAPK11,FGF17,FGFR3,PIK3CB,PIK3R2
    MAPK signaling pathway CACNB2,SRF,PRKACBB,PPP3CA,NR4A1,ATF4,FGF18,FGF11A,MAP2K4,Casp3
    B Cell Receptor Signaling Pathway CDK7,BLK,PDPK1A,CD79B,SYK,ARPC3,NFKBIE,DOK1,PRKCB,RAC2
    Pathways in cancer FH,ETS1,GNB4,PIK3CA,NFKB2,ITGAV,PDGFB,WNT5B,LAMC1,PLCB4
    Ras signaling pathway FGF12,FGF22,GNB1,PLA2G4F,PIK3R5,GAB2,RAP1B,GNG3,PLD1,RALB

    Protein Function

    RASGRP3 has several biochemical functions, for example, GTPase activator activity,Ras GTPase binding,Ras guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RASGRP3 itself. We selected most functions RASGRP3 had, and list some proteins which have the same functions with RASGRP3. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding DGKG,ALOX8,PCDH2G17,PLCZ1,CALN1,PCDH1G2,MCTP1,FREM2,EFHB,PCDH10A
    guanyl-nucleotide exchange factor activity DENND6A,RIC8A,TRIOA,GCGR,TBXAS1,FGD1,CHRM4,RAPGEFL1,DOCK1,GDPGP1
    diacylglycerol binding UNC13A,UNC13C,TRPC2,UNC13B,RASGRP1,RASGRP2,RASGRP4,CDIPT
    signal transducer activity SUFU,OLFR486,GNG11,TAAR12H,RGS7,BAI2,TAAR7F,OLFCG1,ADORA2AA,GPR132
    Ras guanyl-nucleotide exchange factor activity RASGRP4,RGL2,RASGEF1A,RASGEF1BB,SOS1,RASGEF1B,RASGEF1BA,KNDC1,RAPGEF4,RAPGEF5
    GTPase activator activity RALBP1,ARHGAP40,DEPDC1,SH3BP1,ARHGAP23,TBC1D5,TBC1D9,SGSM2,THY1,RGS4
    protein binding HSFX1,CDC20B,ZNF212,RPL13,C21orf7,GBA,NOS3,NUDT2,SLC9A7,TMEM173
    Ras GTPase binding MAP2K1,MLLT4,SH3BP4,RAP1A,PLCE1,MAPKAP1,CIB1,RIN1,SPHK2,RAPGEF4
    kinase binding CAB39,WWC1,TNFAIP3,SP100,JAKMIP2,DLG3,C2orf44,BARD1,RB1,MOB4

    Interacting Protein

    RASGRP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASGRP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASGRP3.

    DYNLL2;YWHAQ;SULT1C2;uxuA

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