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RAPGEF5

Official Full Name

Rap guanine nucleotide exchange factor (GEF) 5
Overview

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated;switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs),;such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and;are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 (PubMed 10934204)).
Synonyms

RAPGEF5; Rap guanine nucleotide exchange factor (GEF) 5; rap guanine nucleotide exchange factor 5; MR-GEF; M-Ras-regulated Rap GEF; guanine nucleotide exchange factor; Mrgef; rMR-GEF; RGD1562891;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Rat
Rhesus Macaque

Source

HEK293
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	RAPGEF5-1469HCL	Recombinant Human RAPGEF5 cell lysate		Non	Inquiry
Rat	RAPGEF5-4928R	Recombinant Rat RAPGEF5 Protein	Mammalian Cell	His	Inquiry
Rat	RAPGEF5-4587R-B	Recombinant Rat RAPGEF5 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rat	RAPGEF5-4587R	Recombinant Rat RAPGEF5 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi	Inquiry
Rhesus Macaque	RAPGEF5-3789R	Recombinant Rhesus monkey RAPGEF5 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	RAPGEF5-3606R-B	Recombinant Rhesus Macaque RAPGEF5 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	RAPGEF5-3606R	Recombinant Rhesus Macaque RAPGEF5 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

RAPGEF5 involved in several pathways and played different roles in them. We selected most pathways RAPGEF5 participated on our site, such as Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAPGEF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ras signaling pathway	PLA2G3;CALM1;FGF8;PAK1;PLA2G2A;RGL2;Pdgfa&Pdgfb;GNG12;GNG13
Rap signaling pathway	MAGI2;FGF12;ITGAL;FGF16;PDGFD;FLT1;P2RY1;KRIT1;PIK3R3

RAPGEF5 has several biochemical functions, for example, GTP-dependent protein binding, Rap guanyl-nucleotide exchange factor activity, Ras guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAPGEF5 itself. We selected most functions RAPGEF5 had, and list some proteins which have the same functions with RAPGEF5. You can find most of the proteins on our site.

Function	Related Protein
GTP-dependent protein binding	ARFIP2;AP3B1;HPS6;RAPGEF5;RAB5B;AP1G1;RAB38;MRAS;PPIAL4A
Rap guanyl-nucleotide exchange factor activity	RAP1A;RAPGEF3;RAPGEF5
Ras guanyl-nucleotide exchange factor activity	RASGRP3;RASGEF1BB;RAPGEF4;RASGRP4;RAB3A;ADRB1;RAPGEF5;RGL2;KNDC1

RAPGEF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAPGEF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAPGEF5.

TMEM253; PLAC9; VANGL1

Research Area

Idevall-Hagren, O; Jakobsson, I; et al. Spatial Control of Epac2 Activity by cAMP and Ca2+-Mediated Activation of Ras in Pancreatic beta Cells. SCIENCE SIGNALING 6:-(2013).

Penzes, P; Woolfrey, KM; et al. Epac2-mediated dendritic spine remodeling: Implications for disease. MOLECULAR AND CELLULAR NEUROSCIENCE 46:368-380(2011).