RAMP2
-
Official Full Name
receptor (G protein-coupled) activity modifying protein 2 -
Overview
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. -
Synonyms
RAMP2;receptor (G protein-coupled) activity modifying protein 2;receptor (calcitonin) activity modifying protein 2 , receptor activity modifying protein 2;receptor activity-modifying protein 2;Calcitonin receptor like receptor activity modifying protein 2;CRLR activity modifying protein 2;OTTMUSP00000002615;OTTMUSP00000037624;Receptor (calcitonin) activity modifying protein 2;Receptor activity modifying protein 2;Receptor activity modifying protein 2 isoform;RP23-281C18.6;CRLR activity-modifying protein 2;receptor-activity-modifying protein 2;calcitonin receptor-like receptor activity modifying protein 2;calcitonin-receptor-like receptor activity-modifying protein 2
Recombinant Proteins
- Human
- Chicken
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RAMP2-2171H | Recombinant Human RAMP2, GST-tagged | E.coli | Human | GST | N-term-148aa | |
| RAMP2-3751C | Recombinant Chicken RAMP2 | Mammalian Cells | Chicken | His |
|
|
| RAMP2-4920R | Recombinant Rat RAMP2 Protein | Mammalian Cells | Rat | His |
|
|
| RAMP2-6403Z | Recombinant Zebrafish RAMP2 | Mammalian Cells | Zebrafish | His |
|
|
| RAMP2-2536HCL | Recombinant Human RAMP2 293 Cell Lysate | HEK293 | Human | Non |
|
|
| RAMP2-2010H | Recombinant Human RAMP2 Protein, His&GST-tagged | E.coli | Human | His&GST | Gln43-Val145 |
|
| RAMP2-4579R | Recombinant Rat RAMP2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| RAMP2-4579R-B | Recombinant Rat RAMP2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
||
| Ramp2-6782M | Recombinant Mouse Ramp2 Protein (Ser45-Val159), C-His tagged | E.coli | Mouse | His | Ser45-Val159 |
|
| Ramp2-6783M | Recombinant Mouse Ramp2 Protein (Ser45-Val159), C-His tagged | Mammalian Cells | Mouse | His | Ser45-Val159 |
|
| RFL7189HF | Recombinant Full Length Human Receptor Activity-Modifying Protein 2(Ramp2) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length of Mature Protein (43-175) |
|
Involved Pathway
RAMP2 involved in several pathways and played different roles in them. We selected most pathways RAMP2 participated on our site, such as Calcitonin-like ligand receptors,Class B/2 (Secretin family receptors),G alpha (s) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAMP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G alpha (s) signalling events | CALCA,ADCYAP1B,CRH,ADRB3,GCGA,POMCB,GCGB,RXFP2B,SCT,CRHB |
| Class B/2 (Secretin family receptors) | RCA2.1,PTH2,PTHLH,GCGB,GNB3B,CRH,EMR1,ADCYAP1B,CRHR2,ADCYAP1 |
| Signal Transduction | ARAP1,PROK2,CCL19A.2,GPRC6A,ARHGAP25,ABI1A,SEPT7,PTGDR2,OR52B4,RLN1 |
| Calcitonin-like ligand receptors | ADM2A,RAMP1,CALCRL,ADM,RAMP3,CALCB,CALCA,ADM2 |
| GPCR downstream signaling | RGS17,RGS10,HRH3,PRKCHB,GPBAR1,S1PR5B,GHRH,ADRA2A,RGS7,CCR8 |
| Signaling by GPCR | OXGR1A.3,ANXA1C,OPN5,TAAR1,RGS4,OPN4.1,RGS10,SST1.1,ARHGEF1B,UTS2 |
| GPCR ligand binding | UTS2D,CCR3,LPAR5A,OPN4A,ADORA1,OPN1SW,RAMP1,OPN1LW1,HCAR1-2,CALCB |
| Myometrial Relaxation and Contraction Pathways | CNN2,RGS18,IGFBP2,RAMP1,IGFBP4,CRCP,RGS5,RGS16,CORIN,ADM |
Protein Function
RAMP2 has several biochemical functions, for example, coreceptor activity,protein binding,protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAMP2 itself. We selected most functions RAMP2 had, and list some proteins which have the same functions with RAMP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GRIN1,EPHA2,BPIFA2,TNFRSF12A,KCNJ10,DYNLL1,DHRS1,cgr2b,IFNA4,GDF2 |
| protein transporter activity | IPO9,KPNA1,IPO8,SEC62,AP1G1,AP1G2,VPS26BL,KPNA4,COX18,XPO1 |
| coreceptor activity | RAMP3,CXCR7B,ACKR3B,CD86,CD80,CCR5,LY96,CD28,HFE2,RGMB |
Interacting Protein
RAMP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAMP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAMP2.
CALCRL
Resources
Related Services
Related Products
References
- Berenguer-Daize, C; Boudouresque, F; et al. Adrenomedullin Blockade Suppresses Growth of Human Hormone-Independent Prostate Tumor Xenograft in Mice. CLINICAL CANCER RESEARCH 19:6138-6150(2013).
- Iesato, Y; Toriyama, Y; et al. Adrenomedullin-RAMP2 System Is Crucially Involved in Retinal Angiogenesis. AMERICAN JOURNAL OF PATHOLOGY 182:2380-2390(2013).
