RALBP1
-
Official Full Name
ralA binding protein 1 -
Overview
RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010] -
Synonyms
RALBP1;ralA binding protein 1;RIP1;RLIP1;RLIP76;ralA-binding protein 1;DNP-SG ATPase;ral-interacting protein 1;76 kDa Ral-interacting protein;dinitrophenyl S-glutathione ATPase
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi&Fc&His
- Flag
- DDK&Myc
Involved Pathway
RALBP1 involved in several pathways and played different roles in them. We selected most pathways RALBP1 participated on our site, such as EGFR1 Signaling Pathway,Pancreatic cancer,Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with RALBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | INS,GAB1,PIK3R1,RASAL3,RAB5B,GNGT1,RAC1,NFKB1,GNB2,PLA2G4F |
| RalA downstream regulated genes | EXOC8 |
| Pathways in cancer | STAT1,RUNX1,FGF20,CBLB,CDC42,BDKRB1,WNT3,FGF22,PRKACG,MAPK9 |
| Rho GTPase cycle | MCF2L,ARHGAP12B,DEPDC1B,FAM13A,STARD8,ARHGAP4A,ARHGEF18,GDI1,ARHGAP23,ECT2 |
| Regulation of RAC1 activity | ARHGAP9,SPATA13,DEF6,PREX2,CHN1,ARHGAP17,RAP1GDS1,ABR,DOCK6,EPS8 |
| Regulation of CDC42 activity | DOCK10,ARHGAP1,ARHGEF25,DOCK6,DNMBP,SPATA13,ARHGAP17,DOCK9,ITSN2,MCF2L |
| EGFR1 Signaling Pathway | GRB14,ELF3,ZFP259,KRT17,REPS2,APPL2,SH2D3C,RBBP7,CRKL,ERRFI1 |
| Pancreatic cancer | MAPK3,TP53,TGFBR2,SMAD2,IKBKG,CASP9,AKT2,TGFB1,RB1,BRAF |
Protein Function
RALBP1 has several biochemical functions, for example, ATPase activity,ATPase activity, coupled to movement of substances,GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RALBP1 itself. We selected most functions RALBP1 had, and list some proteins which have the same functions with RALBP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rac GTPase binding | DOCK7,PAK7,NCF2,PAK2B,PAK1,FLNA,SRGAP3,NOXA1,PAK3,NOX1 |
| GTPase activator activity | ASAP2,GIT2B,ARHGDIG,ARFGAP3,PLEKHG6,DOCK4,LLGL1,ARHGAP36,TBC1D17,RASA3 |
| Ral GTPase binding | RAB34,PIH1D2,LSM2,EXOC4,RNF41,MYO1C,EXOC5,PRKCH,FLNA,EXOC8 |
| ATPase activity | EIF4A2,ABCA5,KIFC3,ABCA4A,KIF3C,PSMC5,ABCD3,RNF213,KIF4A,MYH9 |
| transmembrane transporter activity | ATP5C1,SV2BA,SLC2A15B,CX43,ATP5I,ATP5O,SLC2A1A,SLC22A16,SLC2A11B,ATP5J |
| protein binding | PUM2,AGTR2,TFF2,UBE2V2,TUBB4A,CTC1,PPIA,SNRPD3,RUVBL1,MRE11A |
Interacting Protein
RALBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RALBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RALBP1.
CEP57;CCL20;TAX1BP1;AP2M1;TFPT;PPL
Resources
Research Area
Apoptosis Adaptor ProteinsRegulator of NFkB
Intracellular Kinases in the Akt Pathway
NOD-like Receptors and the Inflammasome
RIG-I-like Receptors
Related Services
Related Products
References
- Drake, KJ; Singhal, J; et al. RALBP1/RLIP76 mediates multidrug resistance. INTERNATIONAL JOURNAL OF ONCOLOGY 30:139-144(2007).
- Chao, LJ; Lu, L; et al. Identification of a Human Protein-Derived HIV-1 Fusion Inhibitor Targeting the gp41 Fusion Core Structure. PLOS ONE 8:-(2013).
