RAD9A

  • Official Full Name

    RAD9 homolog A

  • Overview

    Cell cycle checkpoint control protein RAD9A is a protein that in humans is encoded by the RAD9A gene. This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for this gene.

  • Synonyms

    RAD9A;RAD9 homolog A (S. pombe);RAD9, RAD9 (S. pombe) homolog;cell cycle checkpoint control protein RAD9A;hRAD9;DNA repair exonuclease rad9 homolog A;RAD9

Recombinant Proteins

  • Human
  • Chicken
  • Cynomolgus
  • Mouse
  • Insect Cell
  • Mammalian Cell
  • HEK293
  • HEK293T
  • Non
  • His
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
RAD9A-2385H Recombinant Human RAD9 Homolog A (S. Pombe) Insect Cell Human Non
RAD9A-7136C Recombinant Chicken RAD9A Mammalian Cell Chicken His
RAD9A-840C Recombinant Cynomolgus RAD9A Protein, His-tagged Mammalian Cell Cynomolgus His
RAD9A-2551HCL Recombinant Human RAD9A 293 Cell Lysate HEK293 Human Non
Rad9a-5353M Recombinant Mouse Rad9a Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
RAD9A-583C Recombinant Cynomolgus Monkey RAD9A Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus His&Fc&Avi
RAD9A-583C-B Recombinant Cynomolgus Monkey RAD9A Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus

    Involved Pathway

    RAD9A involved in several pathways and played different roles in them. We selected most pathways RAD9A participated on our site, such as Activation of ATR in response to replication stress,Androgen receptor signaling pathway,Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD9A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    DNA Repair RAD1,GPS1,PIAS3,APITD1,EME1,ASCC2,YY1A,CETN2,DCLRE1A,PPP4R2B
    DNA Double-Strand Break Repair WRN,RAD1,CLSPN,POLD3,TIMELESS,RAD17,BARD1,CHEK1,SMARCA5,UBE2V2
    Cell Cycle Checkpoints HIST4H4,FAM175A,RAD50,UIMC1,DBF4,CHEK2,UBE2V2,RAD17,CDK5RAP2,BRE
    Activation of ATR in response to replication stress RAD1,MCM8,CDK2,DBF4,CHEK1,RAD9,CLSPN,MCM10,RAD17,RAD9B
    G2/M Checkpoints BRE,RNF168,TP53BP1,RAD9,FAM175A,RAD1,HUS1,RAD17,THRSP,UIMC1
    Cell cycle MCM9,ARPP19B,PLK4,SMC1B,CDKN1B,NINL,NCAPD3,SMC4,MAPRE1B,NUF2
    Androgen receptor signaling pathway RNF4,GNB2L1,RHOB,CTNNB2,SMAD3B,STUB1,CREBBP,JUN,HTATIP,HMGB2A
    DNA damage response GADD45A,HUS1B,CHEK2,RAD17,CDK5,GADD45G,DDB2,TLK2,RAD1

    Protein Function

    RAD9A has several biochemical functions, for example, 3-5 exonuclease activity,SH3 domain binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD9A itself. We selected most functions RAD9A had, and list some proteins which have the same functions with RAD9A. You can find most of the proteins on our site.

    Function Related Protein
    SH3 domain binding CCDC6,PTPN22,DRD4,MAPK15,CYBA,CASP9,ADAM15,ARHGAP6,SH3BP5L,SKAP1
    exodeoxyribonuclease III activity RAD1,TREX1,TREX2,RAD9
    3-5 exonuclease activity APLF,POLG,MRE11A,REV3L,POLA1,EXD2,RAD1,EXOSC10,APEX1,REXO2
    protein binding PASK,FTH1,ZNF41,PTPRG,KLHDC3,CRYAB,UPRT,WIPI2,GP9,MIS18A
    histone deacetylase binding BRMS1L,MYOCD,YWHAE,MAGEA1,PARK2,XBP1,SUDS3,YY1,NACC2,NCOR1
    protein kinase binding NIPAL1,SHC1,BORA,DLG1L,PLCG1,KAT2B,AGTR1A,KCNA5,AP2A2,MS4A2
    enzyme binding BTG1,DNMT3L,MAPK8,NLRP1,YES1,UBE2L3,UGT1A9,APP,RCOR1,CAT

    Interacting Protein

    RAD9A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD9A here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD9A.

    HUS1;RAD1;RAD17;TOPBP1;CLSPN;RAD17;SF3B3

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