RAD51C

  • Official Full Name

    RAD51 homolog C

  • Overview

    This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be;involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two;other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein;in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair.;This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast;tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor;progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have;been identified.

  • Synonyms

    RAD51C;RAD51 homolog C (S. cerevisiae);RAD51 (S. cerevisiae) homolog C;DNA repair protein RAD51 homolog 3;RAD51L2;R51H3;RAD51-like protein 2;yeast RAD51 homolog 3;RAD51 homolog C, isoform 1;FANCO;BROVCA3;MGC104277

Recombinant Proteins

  • Mouse
  • Zebrafish
  • Human
  • Mammalian Cell
  • Wheat Germ
  • E.coli
  • HEK293
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
RAD51C-13872M Recombinant Mouse RAD51C Protein Mammalian Cell Mouse His
RAD51C-1607Z Recombinant Zebrafish RAD51C Mammalian Cell Zebrafish His
RAD51C-28601TH Recombinant Human RAD51C Wheat Germ Human Non 134 amino acids
RAD51C-680H Recombinant Human RAD51C Protein, His-tagged E.coli Human His
RAD51C-2555HCL Recombinant Human RAD51C 293 Cell Lysate HEK293 Human Non
RAD51C-7387M Recombinant Mouse RAD51C Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
RAD51C-7387M-B Recombinant Mouse RAD51C Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    RAD51C involved in several pathways and played different roles in them. We selected most pathways RAD51C participated on our site, such as Homologous recombination,Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD51C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Fanconi Anemia Pathway FANCM,SLX1B,ERCC4,ERCC1,RPA3,RPA1,REV1,DCLRE1A,PMS2,FANCA
    Homologous recombination RPA3,RAD51L3,XRCC3,RAD52,POLD1,SSBP1,XRCC2,RAD54B,NBN,MRE11A

    Protein Function

    RAD51C has several biochemical functions, for example, ATP binding,DNA binding,DNA-dependent ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD51C itself. We selected most functions RAD51C had, and list some proteins which have the same functions with RAD51C. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to crossover junction endodeoxyribonuclease activity SLX4,XRCC3
    protein binding NEUROG3,KIAA0649,PTS,H2-KE2,PITX1,NCL,C7orf50,BSG,HSPA14,SEPT1
    single-stranded DNA binding LONP1,BRCA2,RBMS1,OBFC2B,HSPD1,TSNAX,ERCC5,POLR2G,RAD51,IGHMBP2
    contributes_to four-way junction DNA binding XRCC2,RAD51L3,MSH2,XRCC3,RAD51D,RAD51L1,RAD51B,MSH6
    DNA-dependent ATPase activity RAD51L1,SMARCA2,XRCC3,RAD51L3,RAD51D,CDK7,IGHMBP2,MSH4,CHD6,DHX36
    DNA binding CASZ1,ALS2CR8,HMGA1A,PC,CTC1,ORC1L,SOX12,REV3L,POU5F1,MECP2
    ATP binding TTN,DDX18,ABCC2,CDKL4,DDX27,ACTA1,RPS6KA4,TUT1,DDX53,PIK3CD
    recombinase activity RAD51D,RAD51,RBPJ,RAD51L3,DMC1,XRCC3,RAD51B,RAD51L1,XRCC2
    double-stranded DNA binding GATA1A,NTHL1,TP73,TDP1,AIM2,XRCC2,RAD51L1,TP63,MTERFD1,SETMAR

    Interacting Protein

    RAD51C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD51C here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD51C.

    XRCC3;RAD51B;RAD51D

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