RAD23A
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Official Full Name
RAD23 homolog A -
Overview
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. -
Synonyms
RAD23A;RAD23 homolog A (S. cerevisiae);RAD23 (S. cerevisiae) homolog A;UV excision repair protein RAD23 homolog A;HHR23A;MGC111083;RAD23;yeast homolog;A;HR23A;RAD23, yeast homolog, A
Recombinant Proteins
- Human
- Mouse
- E.coli
- HEK293
- Yeast
- Mammalian cells
- HEK293T
- GST
- Non
- His
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
RAD23A involved in several pathways and played different roles in them. We selected most pathways RAD23A participated on our site, such as Nucleotide excision repair,Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD23A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nucleotide Excision Repair | XPC,BIVM-ERCC5,RFC2,NFRKB,RAD23AB,ACTR5,INO80E,ERCC5,COPS3,COPS7B |
| Protein processing in endoplasmic reticulum | MAN1A,VCP,EIF2AK3,LMAN1,PRKCSH,ATF6,YOD1,RAD23AA,MARCH6,EDEM3 |
Protein Function
RAD23A has several biochemical functions, for example, damaged DNA binding,polyubiquitin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD23A itself. We selected most functions RAD23A had, and list some proteins which have the same functions with RAD23A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | HEPACAM2,ARMCX5-GPRASP2,KRT2,EPN3,PIK3R6,ASUN,SPRR1A,Icosl,FAM20A,E2F8 |
| polyubiquitin binding | RAD18,VCP,RAD23B,DZIP3,PSMD4A,ZFAND6,UBQLN4,PSMD4B,TNIP2,UBXN1 |
| damaged DNA binding | UNG,RPA2,RAD23B,EP300,RAD1,XRCC6,XRCC1,MGMT,RUVBL2,RAD18 |
| single-stranded DNA binding | CDC45,RAD51AP1,POLR2GL,RAD23B,PURA,FUBP1,SSBP3A,LONP1,TREX1,TDP2 |
| ubiquitin-specific protease binding | VCP,PARK7,MARCH6,AMFR,SELS,DERL1,CHMP3,SYVN1,SART3,VPS24 |
Interacting Protein
RAD23A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD23A here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD23A.
PSMD4;TRAF2;TRAF5;TRIP6;ANKRD40;ZBTB44
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