RAD21
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Official Full Name
RAD21 homolog -
Overview
The cohesin complex consists of a heterodimer between SMC1 (SMC1A or B) and SMC3, bound by additional RAD21 and STAG proteins (STAG1, 2, or 3). These proteins form a ring-like structure that mediates the cohesion of two sister chromatids after DNA replica -
Synonyms
RAD21;RAD21 homolog (S. pombe);RAD21 (S. pombe) homolog;double-strand-break repair protein rad21 homolog;hHR21;KIAA0078;SCC1;NXP-1;SCC1 homolog;nuclear matrix protein 1;protein involved in DNA double-strand break repair;HR21;MCD1;NXP1;HRAD21
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RAD21-2639C | Recombinant Chicken RAD21 | Mammalian Cell | Chicken | His |
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| RAD21-3773R | Recombinant Rhesus monkey RAD21 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| RAD21-2560HCL | Recombinant Human RAD21 293 Cell Lysate | HEK293 | Human | Non |
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| RAD21-3590R | Recombinant Rhesus Macaque RAD21 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| RAD21-3590R-B | Recombinant Rhesus Macaque RAD21 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
RAD21 involved in several pathways and played different roles in them. We selected most pathways RAD21 participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | KAT5,NDEL1,CCNB3,E2F4,CDC25A,TCTN2,RANGAP1B,NEK9,CENPA,CENPJ |
Protein Function
RAD21 has several biochemical functions, for example, protein binding,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD21 itself. We selected most functions RAD21 had, and list some proteins which have the same functions with RAD21. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | BARX2,STAG2,DLX2,MAFG,GATA2A,DMRT1,CREB3L4,HSF2,HIF1A,NR1I2 |
| protein binding | CHIC2,RNF220,CTNNA1,BBS1,LRRC75A-AS1,CD209,C11orf57,KLC1,OS9,COA6 |
Interacting Protein
RAD21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD21 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD21.
SMC3;STAG2;WAPAL
Resources
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References
- Suzuki, G; Nishiuchi, C; et al. Cellular localization of mitotic RAD21 with repetitive amino acid motifs in Allium cepa. GENE 514:75-81(2013).
- Degner, SC; Verma-Gaur, J; et al. CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108:9566-9571(2011).
