RAB7B
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Official Full Name
RAB7B, member RAS oncogene family -
Overview
Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway. -
Synonyms
RAB7B;RAB7B, member RAS oncogene family;ras-related protein Rab-7b;MGC9726;MGC16212;Ras related protein Rab 7b;RAB7;Ras-related protein Rab-7
Recombinant Proteins
- Human
- Mouse
- E.coli
- HEK293
- Mammalian Cells
- GST
- Myc&DDK
- Non
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RAB7B-2133H | Recombinant Human RAB7B, GST-tagged | E.coli | Human | GST | 1-199aa | |
| RAB7B-193H | Recombinant Human RAB7B, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| RAB7B-195H | Recombinant Human RAB7B, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| RAB7B-196H | Recombinant Human RAB7B, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| RAB7B-2582HCL | Recombinant Human RAB7B 293 Cell Lysate | HEK293 | Human | Non |
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| RAB7B-2398H | Recombinant Human RAB7B Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| Rab7b-5331M | Recombinant Mouse Rab7b Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| RAB7B-5676HFL | Recombinant Full Length Human RAB7B, Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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Involved Pathway
RAB7B involved in several pathways and played different roles in them. We selected most pathways RAB7B participated on our site, such as Phagosome,Salmonella infection,Amoebiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAB7B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amoebiasis | RAB5C,Casp3,VCL,ACTN1,LAMC1,COL1A2,SERPINB2,IL-8,PLCB4,LAMC3 |
| Salmonella infection | ACTG1,RHOGD,PKN3,MAPK8,TLR5B,IL6,IL8L2,PFN3,RAC1A,MYH9 |
| Phagosome | TUBAL3,CORO1A,FCGR3A,ITGB2,MBL2,ATP6V0E2,ATP6V0E,ACTB1,HLA-DRB3,HLA-B |
Protein Function
RAB7B has several biochemical functions, for example, GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAB7B itself. We selected most functions RAB7B had, and list some proteins which have the same functions with RAB7B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | RHOJ,ARHGAP35,ARL8,RAB32A,MXA,GNAO1,SEPT2,GNA15,IRGE4,TUBG1 |
Interacting Protein
RAB7B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAB7B here. Most of them are supplied by our site. Hope this information will be useful for your research of RAB7B.
RAP1B
Resources
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References
- Day, PM; Thompson, CD; et al. Identification of a Role for the trans-Golgi Network in Human Papillomavirus 16 Pseudovirus Infection. JOURNAL OF VIROLOGY 87:3862-3870(2013).
- Higashi, S; Moore, DJ; et al. Localization of MAP1-LC3 in Vulnerable Neurons and Lewy Bodies in Brains of Patients With Dementia With Lewy Bodies. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 70:264-280(2011).
