RAB3GAP2
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Official Full Name
RAB3 GTPase activating protein subunit 2 (non-catalytic) -
Overview
The protein encoded by this gene belongs to the RAB3 protein family, members of which are involved in regulated exocytosis of neurotransmitters and hormones. This protein forms the Rab3 GTPase-activating complex with RAB3GAP1, where it constitutes the regulatory subunit, whereas the latter functions as the catalytic subunit. This gene has the highest level of expression in the brain, consistent with it having a key role in neurodevelopment. Mutations in this gene are associated with Martsolf syndrome. -
Synonyms
RAB3GAP2;RAB3 GTPase activating protein subunit 2 (non-catalytic);rab3 GTPase-activating protein non-catalytic subunit;DKFZP434D245;KIAA0839;RAB3 GAP150;RGAP-iso;rab3-GAP p150;rab3-GAP regulatory subunit;rab3 GTPase-activating protein 150 kDa sub
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RAB3GAP2-2123H | Recombinant Human RAB3GAP2, His-tagged | E.coli | Human | His | 1-204aa | |
| RAB3GAP2-1254Z | Recombinant Zebrafish RAB3GAP2 | Mammalian Cells | Zebrafish | His |
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| RAB3GAP2-3995C | Recombinant Chicken RAB3GAP2 | Mammalian Cells | Chicken | His |
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| RAB3GAP2-4893R | Recombinant Rat RAB3GAP2 Protein | Mammalian Cells | Rat | His |
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| RAB3GAP2-4552R | Recombinant Rat RAB3GAP2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| RAB3GAP2-4552R-B | Recombinant Rat RAB3GAP2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
RAB3GAP2 involved in several pathways and played different roles in them. We selected most pathways RAB3GAP2 participated on our site, such as Effects of Botulinum toxin, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAB3GAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Effects of Botulinum toxin | CCDC167,CHRNA1,UNC13B |
Protein Function
RAB3GAP2 has several biochemical functions, for example, GTPase activator activity,Rab GTPase binding,contributes_to Rab guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAB3GAP2 itself. We selected most functions RAB3GAP2 had, and list some proteins which have the same functions with RAB3GAP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | ARNT,TCF3A,SDCBP2,PHC2B,HIST1H2AK,PRMT5,TPD52,ITGB1A,HMG20A,H2AFY2 |
| enzyme activator activity | GTF3C4,LTC4S,PRKCD,MMP16,TIMP2,TAB1,TRIM23,CTAGE5,SEC14L2,ASAP2 |
| contributes_to Rab guanyl-nucleotide exchange factor activity | RAB3GAP1 |
| Rab GTPase binding | PPIAL4A,ANXA2,RAB11FIP1,RIN3,AP1G1,RABGGTB,RPH3A,BICD1,ODF2,HPS6 |
| GTPase activator activity | RINL,TBC1D4,RGS2,TBC1D7,RAP1GAP2A,VPS9D1,SRGAP1,RASA3,ARHGDIB,ARHGAP44 |
| enzyme regulator activity | MTMR9,DPM2,ATP6V1H,APOC3,DCP1B,GCLM,BRCC3,PSMD1,PSMD2,RGN |
Interacting Protein
RAB3GAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAB3GAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAB3GAP2.
MAP1LC3A;PTP4A3;ARF6;GSTK1;pi3p;GABARAP
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References
- Park, AK; Liegel, RP; et al. Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice. BMC GENETICS 15:-(2014).
- Spang, N; Feldmann, A; et al. RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy. AUTOPHAGY 10:2297-2309(2014).
