PXDN
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Official Full Name
peroxidasin homolog (Drosophila) -
Overview
Drosophila peroxidasin is an extracellular matrix-associated peroxidase (Horikoshi et al., 1999 (PubMed 10441517)). It;is expressed exclusively in hemocytes derived from head mesoderm at a very early stage of differentiation. Peroxidasin;exists as a homotrimer with a unique hybrid structure that combines an enzymatically functional peroxidase domain with;motifs that are typically found in extracellular matrix-associated proteins. It is a secreted protein that contains a;secretory recognition sequence at its N terminus. Peroxidasin catalyzes hydrogen peroxide-driven radioiodination,;oxidations, and the formation of dityrosine in vitro. It is also thought to function in extracellular matrix;consolidation, phagocytosis, and defense. -
Synonyms
PXDN;peroxidasin homolog (Drosophila);peroxidasin homolog;D2S448;D2S448E;KIAA0230;MG50;PRG2;PXN;Melanoma associated antigen MG50;p53 responsive gene 2 protein;Vascular peroxidase 1;VPO;VPO1;OTTHUMP00000199942;OTTHUMP00000199943;p53-responsive gene 2 protein;melanoma-associated antigen MG50
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
PXDN involved in several pathways and played different roles in them. We selected most pathways PXDN participated on our site, such as phosphate acquisition II, which may be useful for your reference. Also, other proteins which involved in the same pathway with PXDN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PXDN has several biochemical functions, for example, extracellular matrix structural constituent,heme binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PXDN itself. We selected most functions PXDN had, and list some proteins which have the same functions with PXDN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidoreductase activity | GLUD1A,HSDL1,H2-KE6,CYP2AD3,SC4MOL,CYP2C50,IMPDH1B,CYP2C37,CYP2C70,AKR1A1A |
| extracellular matrix structural constituent | COMP,COL27A1,LAMC1,COL1A1B,LAMA4,COL1A1,COL27A1A,MATN3,TINAGL1,COL4A6 |
| peroxidase activity | EPX,DUOX2,GPX7,GPX8,GPX4A,GPX1B,PTGS2A,GPX1A,PRDX5,GPX4B |
| heme binding | TPO,CYP3A43,CYP7A1A,CYP2AA4,HBA-X,CYP46A1.2,CYP2A4,CYP2F2,CYP3A7,CYP4F22 |
| metal ion binding | THAP3,UNC13C,LHX2B,PDE1A,ZNF644A,DNAJA2,GNE,CYP2P9,PRKD2,ITGB7 |
Interacting Protein
PXDN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PXDN here. Most of them are supplied by our site. Hope this information will be useful for your research of PXDN.
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